U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hs2st1 heparan sulfate 2-O-sulfotransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292155, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Hs2st1provided by RGD
Official Full Name
heparan sulfate 2-O-sulfotransferase 1provided by RGD
Primary source
RGD:1305366
See related
Ensembl:ENSRNOG00000012549 AllianceGenome:RGD:1305366
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable heparan sulfate 2-O-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to act upstream of or within gene expression; heparin metabolic process; and ureteric bud formation. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 95.9), Lung (RPKM 94.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2q44
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (236168391..236302186, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (233508018..233641769, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (250467428..250600517, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350128 Neighboring gene uncharacterized LOC134485991 Neighboring gene uncharacterized LOC102549483 Neighboring gene uncharacterized LOC120100962 Neighboring gene selenoprotein F Neighboring gene uncharacterized LOC120100963

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Chromosome 2 Fragment Substitutions in Dahl Salt-Sensitive Rats and RNA Sequencing Identified Enpep and Hs2st1 as Vascular Inflammatory Modulators. Berillo O, et al. Hypertension, 2021 Jan. PMID 33161775, Free PMC Article
  2. The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse. Merry CL, et al. J Biol Chem, 2001 Sep 21. PMID 11457822
  3. Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Bullock SL, et al. Genes Dev, 1998 Jun 15. PMID 9637690, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chromosome 2 Fragment Substitutions in Dahl Salt-Sensitive Rats and RNA Sequencing Identified Enpep and Hs2st1 as Vascular Inflammatory Modulators.
    Title: Chromosome 2 Fragment Substitutions in Dahl Salt-Sensitive Rats and RNA Sequencing Identified Enpep and Hs2st1 as Vascular Inflammatory Modulators.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparan sulfate 2-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparan sulfate 2-O-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heparin metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ureteric bud formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
heparan sulfate 2-O-sulfotransferase 1
NP_001093988.1
XP_008759717.1
XP_038957802.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100518.1 → NP_001093988.1  heparan sulfate 2-O-sulfotransferase 1

    See identical proteins and their annotated locations for NP_001093988.1

    Status: PROVISIONAL

    Source sequence(s)
    AY724508, BC091291, BQ194342, CK839839, DY318006, FM092358, FM104316
    UniProtKB/TrEMBL
    A6HW92, G3V7N0
    Related
    ENSRNOP00000016872.4, ENSRNOT00000016872.8
    Conserved Domains (1) summary
    pfam03567
    Location:71 → 326
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    236168391..236302186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761495.4 → XP_008759717.1  heparan sulfate 2-O-sulfotransferase 1 isoform X1

    Conserved Domains (1) summary
    pfam03567
    Location:71 → 327
    Sulfotransfer_2; Sulfotransferase family

  2. XM_039101874.2 → XP_038957802.1  heparan sulfate 2-O-sulfotransferase 1 isoform X2

    Conserved Domains (1) summary
    cl22970
    Location:71 → 161
    Sulfotransfer_2; Sulfotransferase family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous