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Rmnd1 required for meiotic nuclear division 1 homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 292268, updated on 13-Apr-2024

Summary

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Official Symbol
Rmnd1provided by RGD
Official Full Name
required for meiotic nuclear division 1 homologprovided by RGD
Primary source
RGD:1309546
See related
Ensembl:ENSRNOG00000019501 AllianceGenome:RGD:1309546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Iag-1; RGD1309546
Summary
Predicted to be involved in positive regulation of mitochondrial translation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 11. Orthologous to human RMND1 (required for meiotic nuclear division 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 165.7), Adrenal (RPKM 160.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rmnd1 in Genome Data Viewer
Location:
1q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (43265207..43299748, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (40859829..40894376, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (40948843..40982669, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 12 Neighboring gene zinc finger and BTB domain containing 2 Neighboring gene zinc finger and BTB domain containing 2 like Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene uncharacterized LOC134482620

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Implantation-associated gene-1 (Iag-1): a novel gene involved in the early process of embryonic implantation in rat. Xia HF, et al. Hum Reprod, 2008 Jul. PMID 18296448
  2. RMND1 deficiency associated with neonatal lactic acidosis, infantile onset renal failure, deafness, and multiorgan involvement. Janer A, et al. Eur J Hum Genet, 2015 Oct. PMID 25604853, Free PMC Article
  3. Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects. Li D, et al. Sci Total Environ, 2023 Apr 15. PMID 36690096
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
    Title: Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
  2. Overexpression of Iag-1 can inhibit endometrial stromal cell proliferation and induce endometrial stroma cells apoptosis, and p53 and Bax may play an important role in the process of Iag-1-induced apoptosis.
    Title: Implantation-associated gene-1 (Iag-1): a novel gene involved in the early process of embryonic implantation in rat.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
required for meiotic nuclear division protein 1 homolog
Names
implantation-associated gene-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040128.2 → NP_001035217.2  required for meiotic nuclear division protein 1 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6KIL2, E9PU34
    Related
    ENSRNOP00000057484.3, ENSRNOT00000060757.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    43265207..43299748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103392.1 → XP_038959320.1  required for meiotic nuclear division protein 1 homolog isoform X1

    UniProtKB/TrEMBL
    A6KIL2, E9PU34, Q1W176
    Conserved Domains (1) summary
    pfam02582
    Location:227 → 404
    DUF155; Uncharacterized ACR, YagE family COG1723

  2. XM_017588871.3 → XP_017444360.1  required for meiotic nuclear division protein 1 homolog isoform X1

    UniProtKB/TrEMBL
    A6KIL2, E9PU34, Q1W176
    Conserved Domains (1) summary
    pfam02582
    Location:227 → 404
    DUF155; Uncharacterized ACR, YagE family COG1723

  3. XM_039103400.2 → XP_038959328.1  required for meiotic nuclear division protein 1 homolog isoform X1

    UniProtKB/TrEMBL
    A6KIL2, E9PU34, Q1W176
    Conserved Domains (1) summary
    pfam02582
    Location:227 → 404
    DUF155; Uncharacterized ACR, YagE family COG1723

  4. XM_039103410.2 → XP_038959338.1  required for meiotic nuclear division protein 1 homolog isoform X1

    UniProtKB/TrEMBL
    A6KIL2, E9PU34, Q1W176
    Conserved Domains (1) summary
    pfam02582
    Location:227 → 404
    DUF155; Uncharacterized ACR, YagE family COG1723

  5. XM_039103441.2 → XP_038959369.1  required for meiotic nuclear division protein 1 homolog isoform X4

    Conserved Domains (1) summary
    pfam02582
    Location:6 → 160
    DUF155; Uncharacterized ACR, YagE family COG1723

  6. XM_039103420.1 → XP_038959348.1  required for meiotic nuclear division protein 1 homolog isoform X2

    Conserved Domains (1) summary
    pfam02582
    Location:227 → 313
    DUF155; Uncharacterized ACR, YagE family COG1723

  7. XM_039103431.2 → XP_038959359.1  required for meiotic nuclear division protein 1 homolog isoform X3

    Conserved Domains (1) summary
    cl00751
    Location:117 → 239
    DUF155; Uncharacterized ACR, YagE family COG1723

RNA

  1. XR_005500480.1 RNA Sequence

  2. XR_005500484.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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