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F10 coagulation factor X [ Rattus norvegicus (Norway rat) ]

Gene ID: 29243, updated on 4-Jan-2025

Summary

Official Symbol
F10provided by RGD
Official Full Name
coagulation factor Xprovided by RGD
Primary source
RGD:61850
See related
EnsemblRapid:ENSRNOG00000033444 AllianceGenome:RGD:61850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phospholipid binding activity and serine-type endopeptidase activity. Predicted to be involved in blood coagulation and positive regulation of TOR signaling. Predicted to be active in extracellular space. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in breast cancer and factor X deficiency. Orthologous to human F10 (coagulation factor X). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 1929.7) See more
Orthologs
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Genomic context

See F10 in Genome Data Viewer
Location:
16q12.5
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (83170973..83190280, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76468834..76488141, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81803169..81822476, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482531 Neighboring gene PCI domain containing 2 Neighboring gene small ribosomal subunit protein eS19-like Neighboring gene protein Z, vitamin K-dependent plasma glycoprotein Neighboring gene coagulation factor VII Neighboring gene MCF.2 cell line derived transforming sequence-like Neighboring gene uncharacterized LOC134482421

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC108722

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding  
enables phospholipid binding  
enables phospholipid binding  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity  
Process Evidence Code Pubs
involved_in blood coagulation  
involved_in blood coagulation  
involved_in positive regulation of TOR signaling  
involved_in positive regulation of TOR signaling  
involved_in proteolysis  
Component Evidence Code Pubs
is_active_in extracellular space  
located_in extracellular space  

General protein information

Preferred Names
coagulation factor X
Names
coagulation factor 10
stuart factor
NP_058839.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017143.2NP_058839.1  coagulation factor X precursor

    See identical proteins and their annotated locations for NP_058839.1

    Status: VALIDATED

    Source sequence(s)
    BC088151
    UniProtKB/Swiss-Prot
    Q63207
    UniProtKB/TrEMBL
    A0A0H2UHR6, A6IWK2
    Related
    ENSRNOP00000026677.5, ENSRNOT00000026677.8
    Conserved Domains (4) summary
    smart00069
    Location:2384
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:86122
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:232462
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:129164
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    83170973..83190280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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