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Bicra BRD4 interacting chromatin remodeling complex associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 292622, updated on 30-Mar-2024

Summary

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Official Symbol
Bicraprovided by RGD
Official Full Name
BRD4 interacting chromatin remodeling complex associated proteinprovided by RGD
Primary source
RGD:1306385
See related
Ensembl:ENSRNOG00000011262 AllianceGenome:RGD:1306385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gltscr1
Summary
Predicted to enable transcription regulator activator activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome. Orthologous to human BICRA (BRD4 interacting chromatin remodeling complex associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 31.9), Thymus (RPKM 22.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bicra in Genome Data Viewer
Location:
1q21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (85790093..85867656, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (76661897..76736146, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (77869020..77943828, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 23 Neighboring gene NOP53 ribosome biogenesis factor Neighboring gene EH-domain containing 2 Neighboring gene uncharacterized LOC103691043 Neighboring gene zinc finger protein 541 Neighboring gene NSF attachment protein alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. Alpsoy A, et al. J Biol Chem, 2018 Mar 16. PMID 29374058, Free PMC Article
  2. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Rahman S, et al. Mol Cell Biol, 2011 Jul. PMID 21555454, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription regulator activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BRD4-interacting chromatin-remodeling complex-associated protein
Names
BRD4 interacting chromatin remodelling complex associated protein
glioma tumor suppressor candidate region gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106226.2 → NP_001099696.2  BRD4-interacting chromatin-remodeling complex-associated protein

    See identical proteins and their annotated locations for NP_001099696.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6J889, D3ZQW8
    Conserved Domains (1) summary
    pfam15249
    Location:1096 → 1200
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    85790093..85867656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228344.5 → XP_006228406.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6A4I1, A6J889
    Related
    ENSRNOP00000086008.1
    Conserved Domains (1) summary
    pfam15249
    Location:1074 → 1178
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  2. XM_006228345.5 → XP_006228407.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZXV5, A6J889
    Related
    ENSRNOP00000084339.1
    Conserved Domains (1) summary
    pfam15249
    Location:1037 → 1141
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  3. XM_006228343.5 → XP_006228405.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X1

    See identical proteins and their annotated locations for XP_006228405.1

    UniProtKB/TrEMBL
    A6J889, D3ZQW8
    Related
    ENSRNOP00000015059.5
    Conserved Domains (1) summary
    pfam15249
    Location:1096 → 1200
    GLTSCR1; Conserved region of unknown function on GLTSCR protein
Nucleotide Protein Strain
Heading Accession and Version

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