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Plekhg2 pleckstrin homology and RhoGEF domain containing G2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292750, updated on 6-Jun-2024

Summary

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Official Symbol
Plekhg2provided by RGD
Official Full Name
pleckstrin homology and RhoGEF domain containing G2provided by RGD
Primary source
RGD:1310112
See related
Ensembl:ENSRNOG00000030266 AllianceGenome:RGD:1310112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310112
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of actin filament polymerization. Orthologous to human PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 48.4), Spleen (RPKM 39.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plekhg2 in Genome Data Viewer
Location:
1q21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (92779449..92792610, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (83651902..83665063, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (85386492..85399699)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene small nucleolar RNA SNORA40 Neighboring gene ribosomal protein S16 Neighboring gene transfer RNA isoleucine (anticodon UAU) 1 Neighboring gene zinc finger protein 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Microcephaly-dystonia due to mutated PLEKHG2 with impaired actin polymerization. Edvardson S, et al. Neurogenetics, 2016 Jan. PMID 26573021
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC189384

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family G member 2
Names
pleckstrin homology domain containing, family G (with RhoGef domain) member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134972.2 → NP_001128444.1  pleckstrin homology domain-containing family G member 2 isoform 2

    See identical proteins and their annotated locations for NP_001128444.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A1W2Q6B3, A6J9I5, G3V9A0
    Related
    ENSRNOP00000040619.3, ENSRNOT00000044326.4
    Conserved Domains (3) summary
    cd13243
    Location:259 → 409
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:333 → 405
    PH; PH domain
    pfam00621
    Location:102 → 278
    RhoGEF; RhoGEF domain

  2. NM_001415791.1 → NP_001402720.1  pleckstrin homology domain-containing family G member 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A1W2Q6B3
    Related
    ENSRNOP00000096483.1, ENSRNOT00000093265.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    92779449..92792610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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