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Adamts17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293004, updated on 5-Mar-2024

Summary

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Official Symbol
Adamts17provided by RGD
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 17provided by RGD
Primary source
RGD:1308783
See related
Ensembl:ENSRNOG00000037080 AllianceGenome:RGD:1308783
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS17 (ADAM metallopeptidase with thrombospondin type 1 motif 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 65.0), Kidney (RPKM 15.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q22
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (129856062..130178430)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (120445800..120768204)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (127802872..128126764)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene lines homolog 1 Neighboring gene ceramide synthase 3 Neighboring gene heat shock cognate 71 kDa protein-like Neighboring gene uncharacterized LOC120097339 Neighboring gene uncharacterized LOC120097340 Neighboring gene uncharacterized LOC134483668

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 17
Names
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    129856062..130178430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094338.2 → XP_038950266.1  A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform X2

    Conserved Domains (7) summary
    smart00209
    Location:544 → 596
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:230 → 447
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:698 → 808
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:35 → 179
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:464 → 531
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:834 → 886
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cl00292
    Location:168 → 244
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

  2. XM_218753.11 → XP_218753.6  A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform X1

    See identical proteins and their annotated locations for XP_218753.6

    UniProtKB/TrEMBL
    A0A8I5ZWR9, D4ABB3
    Related
    ENSRNOP00000052730.4
    Conserved Domains (8) summary
    smart00209
    Location:544 → 596
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:230 → 447
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam00090
    Location:893 → 946
    TSP_1; Thrombospondin type 1 domain
    pfam01421
    Location:230 → 447
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:61 → 179
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:698 → 808
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1080 → 1106
    PLAC; PLAC (protease and lacunin) domain
    cl00292
    Location:168 → 244
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
Nucleotide Protein Strain
Heading Accession and Version

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