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Arl4a ADP-ribosylation factor like GTPase 4A [ Rattus norvegicus (Norway rat) ]

Gene ID: 29308, updated on 11-Apr-2024

Summary

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Official Symbol
Arl4aprovided by RGD
Official Full Name
ADP-ribosylation factor like GTPase 4Aprovided by RGD
Primary source
RGD:2152
See related
Ensembl:ENSRNOG00000069300 AllianceGenome:RGD:2152
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Arl4
Summary
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to act upstream of or within brown fat cell differentiation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ARL4A (ADP ribosylation factor like GTPase 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 215.8), Spleen (RPKM 101.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (62809287..62811297, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (57079496..57084156, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (59945926..59950586, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10, pseudogene 21 Neighboring gene 60S ribosomal protein L29-like Neighboring gene prohibitin 2, pseudogene 3 Neighboring gene scinderin Neighboring gene leucine-rich single-pass membrane protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene. Schürmann A, et al. Mol Cell Biol, 2002 Apr. PMID 11909968, Free PMC Article
  2. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. Lin CY, et al. J Biol Chem, 2000 Dec 1. PMID 10980193
  3. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. Schürmann A, et al. J Biol Chem, 1994 Jun 3. PMID 8195219
  4. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. Hofmann I, et al. Curr Biol, 2007 Apr 17. PMID 17398095
  5. Wdnm1-like, a new adipokine with a role in MMP-2 activation. Wu Y, et al. Am J Physiol Endocrinol Metab, 2008 Jul. PMID 18492766, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108709

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 4A
Names
ADP-ribosylation factor-like 4
ADP-ribosylation factor-like 4A
ADP-ribosylation-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019186.1 → NP_062059.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_062059.1

    Status: PROVISIONAL

    Source sequence(s)
    X77235
    UniProtKB/Swiss-Prot
    P61214
    UniProtKB/TrEMBL
    A6HBC6
    Related
    ENSRNOP00000084810.1, ENSRNOT00000108440.1
    Conserved Domains (1) summary
    cd04152
    Location:18 → 200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    62809287..62811297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240051.4 → XP_006240113.1  ADP-ribosylation factor-like protein 4A isoform X1

    See identical proteins and their annotated locations for XP_006240113.1

    UniProtKB/Swiss-Prot
    P61214
    UniProtKB/TrEMBL
    A6HBC6
    Related
    ENSRNOP00000089325.1
    Conserved Domains (1) summary
    cd04152
    Location:18 → 200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

  2. XM_006240052.5 → XP_006240114.1  ADP-ribosylation factor-like protein 4A isoform X1

    See identical proteins and their annotated locations for XP_006240114.1

    UniProtKB/Swiss-Prot
    P61214
    UniProtKB/TrEMBL
    A6HBC6
    Conserved Domains (1) summary
    cd04152
    Location:18 → 200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61214.1 GenPept UniProtKB/Swiss-Prot:P61214

Gene LinkOut

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