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Tmem126b transmembrane protein 126B [ Rattus norvegicus (Norway rat) ]

Gene ID: 293114, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem126bprovided by RGD
Official Full Name
transmembrane protein 126Bprovided by RGD
Primary source
RGD:1308371
See related
Ensembl:ENSRNOG00000022732 AllianceGenome:RGD:1308371
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308371
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 29. Orthologous to human TMEM126B (transmembrane protein 126B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 200.3), Kidney (RPKM 170.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem126b in Genome Data Viewer
Location:
1q32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (153852081..153864038, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (144437142..144451508, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (156262220..156274207)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 126A Neighboring gene ribosomal protein L7a, pseudogene 35 Neighboring gene CREB/ATF bZIP transcription factor Neighboring gene discs large MAGUK scaffold protein 2 Neighboring gene ribosomal protein S27a, pseudogene 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in Complex I Assembly Factor TMEM126B Result in Muscle Weakness and Isolated Complex I Deficiency. Sánchez-Caballero L, et al. Am J Hum Genet, 2016 Jul 7. PMID 27374773, Free PMC Article
  2. Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex. Heide H, et al. Cell Metab, 2012 Oct 3. PMID 22982022
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to food ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complex I assembly factor TMEM126B, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106280.2 → NP_001099750.2  complex I assembly factor TMEM126B, mitochondrial

    See identical proteins and their annotated locations for NP_001099750.2

    Status: PROVISIONAL

    Source sequence(s)
    BC167111
    UniProtKB/Swiss-Prot
    B2RZD2, G3V8Z8
    Related
    ENSRNOP00000031739.4, ENSRNOT00000038279.7
    Conserved Domains (1) summary
    pfam07114
    Location:50 → 221
    DUF1370; Protein of unknown function (DUF1370)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    153852081..153864038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105901.2 → XP_038961829.1  complex I assembly factor TMEM126B, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A6I646
    Conserved Domains (1) summary
    pfam07114
    Location:1 → 135
    TMEM126; Transmembrane protein 126

RNA

  1. XR_005501989.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RZD2.2 GenPept UniProtKB/Swiss-Prot:B2RZD2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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