Xpo6 exportin 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Xpo6provided by RGD
Official Full Name: exportin 6provided by RGD
Primary source: RGD:1311491
See related: Ensembl:ENSRNOG00000016722 AllianceGenome:RGD:1311491
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus. Predicted to be located in cytosol; nuclear lumen; and plasma membrane. Predicted to be part of protein-containing complex. Orthologous to human XPO6 (exportin 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 273.3), Spleen (RPKM 189.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190102719..190192138, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (180672114..180761543, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (197500509..197590382, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI010231 (e-PCR)
- UniSTS:249925

RH130571 (e-PCR)
- UniSTS:213855

D1Smu10 (e-PCR)
- UniSTS:517796

RH125206 (e-PCR)
- UniSTS:162028

D1Got166 (e-PCR)
- UniSTS:114680

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear export signal receptor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: exportin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011935.2 → NP_001011935.2 exportin-6

See identical proteins and their annotated locations for NP_001011935.2

Status: VALIDATED

Source sequence(s)

BC083625, CA504675, CA511395, CA512173, CV102769, DV719797, EV776104

UniProtKB/TrEMBL

A6I931, A6I932, G3V858

Related

ENSRNOP00000022502.4, ENSRNOT00000022502.9

Conserved Domains (2) summary

smart00913
Location:31 → 96

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:103 → 277

Xpo1; Exportin 1-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

190102719..190192138 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286040.1 → XP_063142110.1 exportin-6 isoform X3
XM_039107197.2 → XP_038963125.1 exportin-6 isoform X2

UniProtKB/TrEMBL

A6I932

Conserved Domains (2) summary

smart00913
Location:31 → 96

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:103 → 251

Xpo1; Exportin 1-like protein
XM_008759870.3 → XP_008758092.1 exportin-6 isoform X1

UniProtKB/TrEMBL

A6I932

Related

ENSRNOP00000074811.2

Conserved Domains (2) summary

smart00913
Location:31 → 96

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:103 → 277

Xpo1; Exportin 1-like protein
XM_039107205.1 → XP_038963133.1 exportin-6 isoform X4