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Qprt quinolinate phosphoribosyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 293504, updated on 5-Mar-2024

Summary

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Official Symbol
Qprtprovided by RGD
Official Full Name
quinolinate phosphoribosyltransferaseprovided by RGD
Primary source
RGD:1310309
See related
Ensembl:ENSRNOG00000016980 AllianceGenome:RGD:1310309
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables nicotinate-nucleotide diphosphorylase (carboxylating) activity. Involved in NAD biosynthetic process and quinolinate metabolic process. Located in cytoplasm. Used to study Huntington's disease. Orthologous to human QPRT (quinolinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 337.4), Kidney (RPKM 190.3) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Qprt in Genome Data Viewer
Location:
1q37
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191148715..191164006, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181718189..181733486, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198544262..198559556, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 16 open reading frame 54 Neighboring gene uncharacterized LOC134483871 Neighboring gene uncharacterized LOC120099934 Neighboring gene uncharacterized LOC134483868 Neighboring gene sialophorin Neighboring gene uncharacterized LOC134483874

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis. Youn HS, et al. Sci Rep, 2016 Jan 25. PMID 26805589, Free PMC Article
  2. The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid. Malik SS, et al. Proteins, 2014 Mar. PMID 24038671
  3. Crystal structure of Sus scrofa quinolinate phosphoribosyltransferase in complex with nicotinate mononucleotide. Youn HS, et al. PLoS One, 2013. PMID 23626766, Free PMC Article
  4. Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens. Liu H, et al. J Mol Biol, 2007 Oct 26. PMID 17868694, Free PMC Article
  5. Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase. Fukuoka SI, et al. Biochim Biophys Acta, 1998 Jan 21. PMID 9473669

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC108807

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in quinolinate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in quinolinate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within quinolinate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in quinolinate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in quinolinate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic complex IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nicotinate-nucleotide pyrophosphorylase [carboxylating]
Names
QAPRTase
QPRTase
nicotinate-nucleotide pyrophosphorylase
NP_001009646.1
XP_006230308.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009646.1 → NP_001009646.1  nicotinate-nucleotide pyrophosphorylase [carboxylating]

    See identical proteins and their annotated locations for NP_001009646.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088177
    UniProtKB/Swiss-Prot
    Q5I0M2
    UniProtKB/TrEMBL
    A0A8I6G1S5, A6I9L4
    Related
    ENSRNOP00000023080.4, ENSRNOT00000023080.6
    Conserved Domains (2) summary
    cd01572
    Location:17 → 284
    QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...
    TIGR00078
    Location:21 → 285
    nadC; nicotinate-nucleotide pyrophosphorylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    191148715..191164006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230246.5 → XP_006230308.1  nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZY87, A6I9L5
    Related
    ENSRNOP00000082607.1
    Conserved Domains (2) summary
    cd01572
    Location:82 → 349
    QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...
    TIGR00078
    Location:86 → 350
    nadC; nicotinate-nucleotide pyrophosphorylase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0M2.1 GenPept UniProtKB/Swiss-Prot:Q5I0M2

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