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Rnf152 ring finger protein 152 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293561, updated on 4-May-2024

Summary

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Official Symbol
Rnf152provided by RGD
Official Full Name
ring finger protein 152provided by RGD
Primary source
RGD:1305251
See related
Ensembl:ENSRNOG00000014859 AllianceGenome:RGD:1305251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable small GTPase binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and protein polyubiquitination. Predicted to be located in lysosome. Predicted to be integral component of organelle membrane. Predicted to be active in lysosomal membrane. Orthologous to human RNF152 (ring finger protein 152). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 175.4), Brain (RPKM 56.1) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnf152 in Genome Data Viewer
Location:
13p11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (21838634..21918000, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (21324039..21403405, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (25183295..25262785, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene high mobility group box 3, pseudogene 2 Neighboring gene cadherin 20 Neighboring gene uncharacterized LOC102547165 Neighboring gene uncharacterized LOC134481471 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. Zhang S, et al. Protein Cell, 2010 Jul. PMID 21203937, Free PMC Article
  2. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. Deng L, et al. Mol Cell, 2015 Jun 4. PMID 25936802
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF152
Names
RING-type E3 ubiquitin transferase RNF152
NP_001099775.1
XP_017454255.1
XP_017454256.1
XP_017454257.1
XP_017454258.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106305.3 → NP_001099775.1  E3 ubiquitin-protein ligase RNF152

    See identical proteins and their annotated locations for NP_001099775.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    D4A723
    Related
    ENSRNOP00000019921.4, ENSRNOT00000019921.6
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

  2. NM_001429979.1 → NP_001416908.1  E3 ubiquitin-protein ligase RNF152

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    21838634..21918000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598769.3 → XP_017454258.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    D4A723
    Related
    ENSRNOP00000093523.1
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

  2. XM_017598766.3 → XP_017454255.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    D4A723
    Related
    ENSRNOP00000097172.1
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

  3. XM_017598768.3 → XP_017454257.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    D4A723
    Related
    ENSRNOP00000093936.1
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins

  4. XM_017598767.3 → XP_017454256.1  E3 ubiquitin-protein ligase RNF152 isoform X1

    UniProtKB/Swiss-Prot
    D4A723
    Related
    ENSRNOP00000095982.1
    Conserved Domains (1) summary
    cd16548
    Location:11 → 55
    RING-HC_RNF152; RING finger, HC subclass, found in RING finger protein 152 (RNF152) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4A723.1 GenPept UniProtKB/Swiss-Prot:D4A723

Gene LinkOut

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