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Mus81 MUS81 structure-specific endonuclease subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 293678, updated on 3-Apr-2024

Summary

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Official Symbol
Mus81provided by RGD
Official Full Name
MUS81 structure-specific endonuclease subunitprovided by RGD
Primary source
RGD:1311957
See related
Ensembl:ENSRNOG00000020617 AllianceGenome:RGD:1311957
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 3'-flap endonuclease activity. Predicted to be involved in DNA recombination; mitotic intra-S DNA damage checkpoint signaling; and osteoblast proliferation. Predicted to act upstream of or within DNA catabolic process, endonucleolytic and response to intra-S DNA damage checkpoint signaling. Predicted to be located in nucleolus. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 82.5), Heart (RPKM 71.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212219793..212225214, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202790295..202796008, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220862474..220867973, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cathepsin W Neighboring gene EGF containing fibulin extracellular matrix protein 2 Neighboring gene cofilin 1 Neighboring gene sorting nexin 32 Neighboring gene MAGE family member B10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Xing M, et al. Oncotarget, 2015 Nov 10. PMID 26415217, Free PMC Article
  2. FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress. Fugger K, et al. Nat Commun, 2013. PMID 23361013
  3. Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Muñoz IM, et al. Mol Cell, 2009 Jul 10. PMID 19595721
  4. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Svendsen JM, et al. Cell, 2009 Jul 10. PMID 19596235, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112911

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-flap endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables 3'-flap endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to crossover junction DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables crossover junction DNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via break-induced replication IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in osteoblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in replication fork processing IEA
Inferred from Electronic Annotation
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to intra-S DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Holliday junction resolvase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Holliday junction resolvase complex IEA
Inferred from Electronic Annotation
more info
  
part_of endodeoxyribonuclease complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in replication fork IEA
Inferred from Electronic Annotation
more info
  
is_active_in replication fork ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
crossover junction endonuclease MUS81
Names
MUS81 endonuclease homolog
NP_001020816.1
XP_006230809.1
XP_008758328.1
XP_008758329.1
XP_038964323.1
XP_038964328.1
XP_063142919.1
XP_063142923.1
XP_063142925.1
XP_063142926.1
XP_063142927.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025645.1 → NP_001020816.1  crossover junction endonuclease MUS81

    See identical proteins and their annotated locations for NP_001020816.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098853
    UniProtKB/Swiss-Prot
    Q4KM32
    UniProtKB/TrEMBL
    A0A8I5ZVS5, A6HZ68
    Related
    ENSRNOP00000083286.1, ENSRNOT00000101939.1
    Conserved Domains (1) summary
    pfam02732
    Location:273 → 415
    ERCC4; ERCC4 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212219793..212225214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286855.1 → XP_063142925.1  crossover junction endonuclease MUS81 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AEG6

  2. XM_008760106.4 → XP_008758328.1  crossover junction endonuclease MUS81 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZVS5, A0A8L2QFD5
    Related
    ENSRNOP00000028015.5
    Conserved Domains (1) summary
    pfam02732
    Location:285 → 427
    ERCC4; ERCC4 domain

  3. XM_039108395.2 → XP_038964323.1  crossover junction endonuclease MUS81 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZVS5
    Related
    ENSRNOP00000090515.1
    Conserved Domains (2) summary
    cd20074
    Location:278 → 431
    XPF_nuclease_Mus81; XPF-like nuclease domain of Mus81
    cd21036
    Location:130 → 219
    WH_MUS81; winged helix domain found in crossover junction endonuclease MUS81 and similar proteins

  4. XM_063286853.1 → XP_063142923.1  crossover junction endonuclease MUS81 isoform X6

  5. XM_063286849.1 → XP_063142919.1  crossover junction endonuclease MUS81 isoform X3

  6. XM_008760107.3 → XP_008758329.1  crossover junction endonuclease MUS81 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVS5
    Conserved Domains (1) summary
    pfam02732
    Location:278 → 420
    ERCC4; ERCC4 domain

  7. XM_063286856.1 → XP_063142926.1  crossover junction endonuclease MUS81 isoform X8

  8. XM_006230747.5 → XP_006230809.1  crossover junction endonuclease MUS81 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZVS5, A0A8I6AMQ1
    Related
    ENSRNOP00000095258.1
    Conserved Domains (1) summary
    pfam02732
    Location:251 → 383
    ERCC4; ERCC4 domain

  9. XM_039108400.2 → XP_038964328.1  crossover junction endonuclease MUS81 isoform X9

    Conserved Domains (2) summary
    cd20074
    Location:278 → 431
    XPF_nuclease_Mus81; XPF-like nuclease domain of Mus81
    cd21036
    Location:130 → 219
    WH_MUS81; winged helix domain found in crossover junction endonuclease MUS81 and similar proteins

  10. XM_063286857.1 → XP_063142927.1  crossover junction endonuclease MUS81 isoform X10

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KM32.1 GenPept UniProtKB/Swiss-Prot:Q4KM32

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