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Myrf myelin regulatory factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 293736, updated on 6-Jun-2024

Summary

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Official Symbol
Myrfprovided by RGD
Official Full Name
myelin regulatory factorprovided by RGD
Primary source
RGD:1306622
See related
Ensembl:ENSRNOG00000028274 AllianceGenome:RGD:1306622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mrf; RGD1306622
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Predicted to be involved in several processes, including central nervous system myelin maintenance; positive regulation of myelination; and regulation of transcription, DNA-templated. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in endoplasmic reticulum membrane and nucleus. Orthologous to human MYRF (myelin regulatory factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 49.8), Lung (RPKM 39.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Myrf in Genome Data Viewer
Location:
1q43
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216279057..216311155, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (206854175..206886276, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226260558..226292650, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene fatty acid desaturase 1 Neighboring gene transmembrane protein 258 Neighboring gene flap structure-specific endonuclease 1 Neighboring gene diacylglycerol lipase, alpha Neighboring gene ribosomal protein L10, pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Large-Scale Targeted Sequencing Study of Ischemic Stroke in the Han Chinese Population. Shi M, et al. J Am Heart Assoc, 2022 Oct 4. PMID 36193932, Free PMC Article
  2. Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia. Gawlińska K, et al. Int J Mol Sci, 2020 Oct 27. PMID 33120991, Free PMC Article
  3. Oligodendroglia Are Particularly Vulnerable to Oxidative Damage after Neurotrauma In Vivo. Giacci MK, et al. J Neurosci, 2018 Jul 18. PMID 29915135, Free PMC Article
  4. Co-transplantation of MRF-overexpressing oligodendrocyte precursor cells and Schwann cells promotes recovery in rat after spinal cord injury. Xie XM, et al. Neurobiol Dis, 2016 Oct. PMID 27370227
  5. Truncation mutations in MYRF underlie primary angle closure glaucoma. Ouyang J, et al. Hum Genet, 2023 Jan. PMID 36129575

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in central nervous system myelin maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system myelin maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in oligodendrocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of oligodendrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autoprocessing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cocaine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to immobilization stress IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myelin regulatory factor
Names
myelin gene regulatory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170487.1 → NP_001163958.1  myelin regulatory factor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ACZ2, D4A352
    Related
    ENSRNOP00000035676.5, ENSRNOT00000039133.6
    Conserved Domains (5) summary
    pfam05224
    Location:392 → 539
    NDT80_PhoG; NDT80 / PhoG like DNA-binding family
    pfam13884
    Location:586 → 646
    Peptidase_S74; Chaperone of endosialidase
    pfam13887
    Location:666 → 701
    MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
    pfam13888
    Location:1007 → 1138
    MRF_C2; Myelin gene regulatory factor C-terminal domain 2
    cl01455
    Location:278 → 331
    PhnH; Bacterial phosphonate metabolizm protein (PhnH)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    216279057..216311155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231030.5 → XP_006231092.1  myelin regulatory factor isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACZ2
    Conserved Domains (5) summary
    pfam05224
    Location:392 → 539
    NDT80_PhoG; NDT80 / PhoG like DNA-binding family
    pfam13884
    Location:586 → 646
    Peptidase_S74; Chaperone of endosialidase
    pfam13887
    Location:666 → 701
    MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
    pfam13888
    Location:1006 → 1137
    MRF_C2; Myelin gene regulatory factor C-terminal domain 2
    cl01455
    Location:278 → 331
    PhnH; Bacterial phosphonate metabolizm protein (PhnH)

  2. XM_063286961.1 → XP_063143031.1  myelin regulatory factor isoform X5

    UniProtKB/TrEMBL
    A0A8I6ACZ2

  3. XM_008760221.3 → XP_008758443.1  myelin regulatory factor isoform X4

    UniProtKB/TrEMBL
    A0A8I6ARG5
    Related
    ENSRNOP00000096864.1, ENSRNOT00000116485.1
    Conserved Domains (5) summary
    pfam05224
    Location:304 → 451
    NDT80_PhoG; NDT80 / PhoG like DNA-binding family
    pfam13884
    Location:498 → 558
    Peptidase_S74; Chaperone of endosialidase
    pfam13887
    Location:578 → 613
    MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
    pfam13888
    Location:919 → 1050
    MRF_C2; Myelin gene regulatory factor C-terminal domain 2
    cl01455
    Location:190 → 243
    PhnH; Bacterial phosphonate metabolizm protein (PhnH)

  4. XM_008760220.3 → XP_008758442.1  myelin regulatory factor isoform X3

    UniProtKB/TrEMBL
    A0A8I6ACZ2
    Conserved Domains (6) summary
    TIGR02600
    Location:768 → 866
    Verru_Chthon_A; Verru_Chthon cassette protein A
    pfam05224
    Location:392 → 539
    NDT80_PhoG; NDT80 / PhoG like DNA-binding family
    pfam13884
    Location:586 → 646
    Peptidase_S74; Chaperone of endosialidase
    pfam13887
    Location:666 → 701
    MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
    pfam13888
    Location:979 → 1110
    MRF_C2; Myelin gene regulatory factor C-terminal domain 2
    cl01455
    Location:278 → 331
    PhnH; Bacterial phosphonate metabolizm protein (PhnH)

  5. XM_006231031.4 → XP_006231093.1  myelin regulatory factor isoform X2

    UniProtKB/TrEMBL
    A0A8I6ACZ2, A0A8I6AIU7
    Related
    ENSRNOP00000095013.1, ENSRNOT00000094966.1
    Conserved Domains (6) summary
    TIGR02600
    Location:768 → 867
    Verru_Chthon_A; Verru_Chthon cassette protein A
    pfam05224
    Location:392 → 539
    NDT80_PhoG; NDT80 / PhoG like DNA-binding family
    pfam13884
    Location:586 → 646
    Peptidase_S74; Chaperone of endosialidase
    pfam13887
    Location:666 → 701
    MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
    pfam13888
    Location:980 → 1111
    MRF_C2; Myelin gene regulatory factor C-terminal domain 2
    cl01455
    Location:278 → 331
    PhnH; Bacterial phosphonate metabolizm protein (PhnH)
Nucleotide Protein Strain
Heading Accession and Version

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