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Glyat glycine-N-acyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 293779, updated on 13-Apr-2024

Summary

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Official Symbol
Glyatprovided by RGD
Official Full Name
glycine-N-acyltransferaseprovided by RGD
Primary source
RGD:1307163
See related
Ensembl:ENSRNOG00000012142 AllianceGenome:RGD:1307163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable glycine N-acyltransferase activity and glycine N-benzoyltransferase activity. Predicted to be involved in benzoyl-CoA metabolic process; glycine metabolic process; and monocarboxylic acid metabolic process. Predicted to be active in mitochondrion. Orthologous to human GLYAT (glycine-N-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 2161.8) See more
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Genomic context

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See Glyat in Genome Data Viewer
Location:
1q43
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (219128798..219149615)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (209704213..209724949)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (229060125..229081113)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene glycine-N-acyltransferase-like 1 Neighboring gene olfactory receptor family 5 subfamily B member 95 like 1 Neighboring gene olfactory receptor family 5 subfamily B member 95

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enhanced phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies. Wen H, et al. Mol Cell Proteomics, 2013 Mar. PMID 23230277, Free PMC Article
  2. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. Matsuo M, et al. Biochem Biophys Res Commun, 2012 Apr 20. PMID 22475485
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93750

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine N-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycine N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycine N-benzoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine N-benzoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycine N-benzoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycine N-benzoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in benzoyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in benzoyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in monocarboxylic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glycine N-acyltransferase
Names
AAc
acyl-CoA:glycine N-acyltransferase
aralkyl acyl-CoA N-acyltransferase
aralkyl acyl-CoA:amino acid N-acyltransferase
benzoyl-coenzyme A:glycine N-acyltransferase
glycine N-benzoyltransferase
liver regeneration-related protein LRRG067
NP_001009648.1
NP_001399482.1
XP_038964631.1
XP_038964632.1
XP_063143048.1
XP_063143049.1
XP_063143050.1
XP_063143052.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009648.3 → NP_001009648.1  glycine N-acyltransferase

    See identical proteins and their annotated locations for NP_001009648.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q5PQT3, Q7TP56
    UniProtKB/TrEMBL
    A0A0G2JWI5, A4PB92
    Conserved Domains (2) summary
    pfam08444
    Location:207 → 295
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 206
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  2. NM_001412553.1 → NP_001399482.1  glycine N-acyltransferase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q5PQT3, Q7TP56
    UniProtKB/TrEMBL
    A4PB92
    Related
    ENSRNOP00000016454.3, ENSRNOT00000016454.6

RNA

  1. NR_178215.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    219128798..219149615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286978.1 → XP_063143048.1  glycine N-acyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q5PQT3, Q7TP56
    UniProtKB/TrEMBL
    A4PB92

  2. XM_063286980.1 → XP_063143050.1  glycine N-acyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q5PQT3, Q7TP56
    UniProtKB/TrEMBL
    A4PB92

  3. XM_063286979.1 → XP_063143049.1  glycine N-acyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q5PQT3, Q7TP56
    UniProtKB/TrEMBL
    A4PB92

  4. XM_063286982.1 → XP_063143052.1  glycine N-acyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q5PQT3, Q7TP56
    UniProtKB/TrEMBL
    A4PB92

  5. XM_039108703.2 → XP_038964631.1  glycine N-acyltransferase isoform X2

    Conserved Domains (2) summary
    pfam08444
    Location:143 → 231
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 142
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  6. XM_039108704.2 → XP_038964632.1  glycine N-acyltransferase isoform X2

    Conserved Domains (2) summary
    pfam08444
    Location:143 → 231
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 142
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQT3.1 GenPept UniProtKB/Swiss-Prot:Q5PQT3

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