Mag myelin-associated glycoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Magprovided by RGD
Official Full Name: myelin-associated glycoproteinprovided by RGD
Primary source: RGD:3035
See related: Ensembl:ENSRNOG00000021023 AllianceGenome:RGD:3035
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 1B236
Summary: Enables carboxylic acid binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of neuron differentiation; and regulation of neurogenesis. Located in several cellular components, including Schmidt-Lanterman incisure; mesaxon; and myelin sheath adaxonal region. Is integral component of plasma membrane. Used to study middle cerebral artery infarction and sciatic neuropathy. Biomarker of nerve compression syndrome. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 75. Orthologous to human MAG (myelin associated glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 424.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (95275728..95291133, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (86148227..86163726, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (89345325..89360905, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myelin-associated glycoprotein inhibits neurite outgrowth through inactivation of the small GTPase Rap1.
Title: Myelin-associated glycoprotein inhibits neurite outgrowth through inactivation of the small GTPase Rap1.
LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.
Title: LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.
MAG, a RGD tri-peptide containing protein, forms a complex with beta1-integrin to mediate axonal growth cone turning responses of several neuronal types.
Title: beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones.
only nucleotides 1315-1412 show ligand responsiveness to neurotrophin 3 (NT3) and myelin-associated glycoprotein (MAG)
Title: Conserved 3'-untranslated region sequences direct subcellular localization of chaperone protein mRNAs in neurons.
Our results suggest that MAG can inhibit the neuronal differentiation of neural progenitor cells
Title: Myelin-associated glycoprotein inhibits the neuronal differentiation of neural progenitors.
Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells
Title: Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells.
Localisation within lipid rafts may provide a molecular environment that facilitates the interaction between MAG and multiple receptors and also between MAG ligands and molecules involved in signal transduction.
Title: Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons.
Exercise significantly decreased the levels of myelin-associated glycoprotein (MAG), a potent axonal growth inhibitor, suggesting that downregulation of MAG is part of the mechanism through which exercise reduces growth inhibition.
Title: Exercise decreases myelin-associated glycoprotein expression in the spinal cord and positively modulates neuronal growth.
MAG inhibits regeneration by interaction with NgR. Binding of and inhibition by MAG are lost if neuronal GPI-linked proteins are cleaved. Binding of MAG to NgR-expressing cells is GPI dependent and sialic acid independent.
Title: Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth.
induces phosphorylation of CRMP-2 in postnatal cerebellar neurons
Title: Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134668 (e-PCR)
- UniSTS:217947

Mag (e-PCR), detects polymorphism
- UniSTS:143816

UniSTS:143817 (e-PCR)
- UniSTS:143817

Mag (e-PCR), detects polymorphism
- UniSTS:143817

Mag (e-PCR), detects polymorphism
- UniSTS:495846

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables ganglioside GT1b binding	IDA Inferred from Direct Assay more info	PubMed
enables ganglioside GT1b binding	ISO Inferred from Sequence Orthology more info
enables ganglioside GT1b binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables sialic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables sialic acid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables sialic acid binding	ISO Inferred from Sequence Orthology more info
enables sialic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in central nervous system myelin formation	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelination	ISO Inferred from Sequence Orthology more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of astrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within transmission of nerve impulse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Schmidt-Lanterman incisure	IDA Inferred from Direct Assay more info	PubMed
located_in Schmidt-Lanterman incisure	ISO Inferred from Sequence Orthology more info
located_in compact myelin	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in mesaxon	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in myelin sheath adaxonal region	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath adaxonal region	ISO Inferred from Sequence Orthology more info
located_in paranode region of axon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: myelin-associated glycoprotein

Names: S-MAG (C-term.); brain neuron cytoplasmic protein 3; sialic acid-binding Ig-like lectin 4a; siglec-4a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017190.4 → NP_058886.1 myelin-associated glycoprotein precursor

See identical proteins and their annotated locations for NP_058886.1

Status: PROVISIONAL

Source sequence(s)

M16800

UniProtKB/Swiss-Prot

P02685, P07722, P07723

UniProtKB/TrEMBL

A6JA32

Related

ENSRNOP00000028544.2, ENSRNOT00000028544.6

Conserved Domains (5) summary

smart00409
Location:333 → 409

IG; Immunoglobulin

pfam13927
Location:239 → 309

Ig_3; Immunoglobulin domain

cd00096
Location:239 → 242

Ig; Ig strand A [structural motif]

cd05712
Location:22 → 138

IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)

cd20987
Location:141 → 235

IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

95275728..95291133 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008759138.4 → XP_008757360.1 myelin-associated glycoprotein isoform X1

See identical proteins and their annotated locations for XP_008757360.1

UniProtKB/Swiss-Prot

P02685, P07722, P07723

UniProtKB/TrEMBL

A6JA32

Conserved Domains (5) summary

smart00409
Location:333 → 409

IG; Immunoglobulin

pfam13927
Location:239 → 309

Ig_3; Immunoglobulin domain

cd00096
Location:239 → 242

Ig; Ig strand A [structural motif]

cd05712
Location:22 → 138

IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)

cd20987
Location:141 → 235

IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
XM_006228824.5 → XP_006228886.1 myelin-associated glycoprotein isoform X1

See identical proteins and their annotated locations for XP_006228886.1

UniProtKB/Swiss-Prot

P02685, P07722, P07723

UniProtKB/TrEMBL

A6JA32

Conserved Domains (5) summary

smart00409
Location:333 → 409

IG; Immunoglobulin

pfam13927
Location:239 → 309

Ig_3; Immunoglobulin domain

cd00096
Location:239 → 242

Ig; Ig strand A [structural motif]

cd05712
Location:22 → 138

IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)

cd20987
Location:141 → 235

IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
XM_017589051.3 → XP_017444540.1 myelin-associated glycoprotein isoform X1

UniProtKB/Swiss-Prot

P02685, P07722, P07723

UniProtKB/TrEMBL

A6JA32

Conserved Domains (5) summary

smart00409
Location:333 → 409

IG; Immunoglobulin

pfam13927
Location:239 → 309

Ig_3; Immunoglobulin domain

cd00096
Location:239 → 242

Ig; Ig strand A [structural motif]

cd05712
Location:22 → 138

IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)

cd20987
Location:141 → 235

IgC2_CD33_d2_like; Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains
XM_017589054.3 → XP_017444543.1 myelin-associated glycoprotein isoform X2

UniProtKB/TrEMBL

A6JA35, G3V9B3

Conserved Domains (5) summary

cd05712
Location:22 → 139

Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)

smart00408
Location:253 → 312

IGc2; Immunoglobulin C-2 Type

smart00410
Location:333 → 409

IG_like; Immunoglobulin like

pfam07679
Location:240 → 322

I-set; Immunoglobulin I-set domain

cl11960
Location:141 → 219

Ig; Immunoglobulin domain