Ddah2 DDAH family member 2, ADMA-independent [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddah2provided by RGD
Official Full Name: DDAH family member 2, ADMA-independentprovided by RGD
Primary source: RGD:1302955
See related: Ensembl:ENSRNOG00000000842 AllianceGenome:RGD:1302955
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables amino acid binding activity and dimethylargininase activity. Involved in arginine metabolic process. Predicted to be located in mitochondrion. Orthologous to human DDAH2 (dimethylarginine dimethylaminohydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 173.3), Kidney (RPKM 150.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3766115..3769161, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3761460..3764718, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5049260..5052573)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Higher levels of asymmetric dimethylarginine are associated with lower DDAH2 and higher PRMT1 in LPS-induced endometritis rat model.
Title: Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.
Suppression of DDAH2 expression might account for, at least partially, the vascular endothelial dysfunction in hyperlipidemia, and nmMLC20 plays a role in suppression of DDAH2 expression in a phosphorylation-dependent manner.
Title: Phosphorylation of Nonmuscle Myosin Light Chain Promotes Endothelial Injury in Hyperlipidemic Rats Through a Mechanism Involving Downregulation of Dimethylarginine Dimethylaminohydrolase 2.
Low-dose rosuvastatin exerted cardioprotective effects on isoproterenol-induced heart failure in rats by modulating DDAH-ADMA-NO pathway.
Title: Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway.
findings suggested that in the development of type 2 diabetes mellitus, local DDAH-2 in adipocytes might play an important role in regulating insulin sensitivity
Title: The association of adipose-derived dimethylarginine dimethylaminohydrolase-2 with insulin sensitivity in experimental type 2 diabetes mellitus.
The DDAH/asymmetric dimethylarginine pathway participates in the pathogenesis of rheumatoid arthritis and may be mediated by cortistatin.
Title: Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats.
downregulation of DDAH2 and eNOS induced endothelial dysfunction in sinoaortic-denervated
Title: Down-regulation of DDAH2 and eNOS induces endothelial dysfunction in sinoaortic-denervated rats.
Cerebral enzymatic activities, mRNA and protein expression of arginase and DDAH were determined in African trypanosomiasis model of rat.
Title: Cerebral changes occurring in arginase and dimethylarginine dimethylaminohydrolase (DDAH) in a rat model of sleeping sickness.
In healthy hearts, DDAH I is absent and DDAH II is localized to endothelium and endocardium, with a similar distribution to that of eNOS. The levels and activity of DDAH I and DDAH II are increased following myocardial infarction.
Title: Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarction.
Results suggest that alterations in DDAH-2/Nos inhibitors/NO-dependent cyclic GMP/ET-1 pathway are possibly involved in maintaining myometrial quiescence during gestation and controlling delivery at term.
Title: Regulation of myometrial contractivity during pregnancy in the rat: potential role for DDAH.
CAT1, CAT2, DDAH2, and arginase-1 expression in renal resistance vessels is regulated through the AT(1) receptor.
Title: AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128085 (e-PCR)
- UniSTS:211393

Clic1 (e-PCR), detects polymorphism
- UniSTS:499174

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables dimethylargininase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in citrulline metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: putative hydrolase DDAH2

Names: DDAH-2; DDAHII; dimethylargininase-2; dimethylarginine dimethylaminohydrolase 2; inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; inactive dimethylarginine dimethylaminohydrolase 2; n(G),N(G)-dimethylarginine dimethylaminohydrolase 2

NP_001159408.1

EC 3.5.3.18

NP_997697.1

EC 3.5.3.18

XP_008770937.1

EC 3.5.3.18

XP_063135070.1

EC 3.5.3.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001165936.1 → NP_001159408.1 putative hydrolase DDAH2

See identical proteins and their annotated locations for NP_001159408.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC097930, EV770973

UniProtKB/Swiss-Prot

Q6MG60

UniProtKB/TrEMBL

A6KTR6

Conserved Domains (1) summary

cl19186
Location:62 → 277

Amidinotransf; Amidinotransferase
NM_212532.2 → NP_997697.1 putative hydrolase DDAH2

See identical proteins and their annotated locations for NP_997697.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC097930, CO385374

UniProtKB/Swiss-Prot

Q6MG60

UniProtKB/TrEMBL

A6KTR6

Conserved Domains (1) summary

cl19186
Location:62 → 277

Amidinotransf; Amidinotransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

3766115..3769161 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008772715.4 → XP_008770937.1 putative hydrolase DDAH2 isoform X2

Conserved Domains (1) summary

cl19186
Location:62 → 166

Amidinotransf; Amidinotransferase
XM_063279000.1 → XP_063135070.1 putative hydrolase DDAH2 isoform X1