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Mcm3ap minichromosome maintenance complex component 3 associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 294339, updated on 5-Mar-2024

Summary

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Official Symbol
Mcm3approvided by RGD
Official Full Name
minichromosome maintenance complex component 3 associated proteinprovided by RGD
Primary source
RGD:1306834
See related
Ensembl:ENSRNOG00000001272 AllianceGenome:RGD:1306834
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable H3 histone acetyltransferase activity; chromatin binding activity; and histone binding activity. Predicted to be involved in nucleosome organization; poly(A)+ mRNA export from nucleus; and somatic hypermutation of immunoglobulin genes. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be part of nuclear pore nuclear basket and transcription export complex 2. Predicted to be active in cytoplasm and nucleus. Orthologous to human MCM3AP (minichromosome maintenance complex component 3 associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 166.1), Lung (RPKM 117.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mcm3ap in Genome Data Viewer
Location:
20p12
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12127060..12164651, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12127570..12165165, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (12879304..12917069, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483885 Neighboring gene spermatogenesis and centriole associated 1-like Neighboring gene lanosterol synthase Neighboring gene similar to human chromosome 21 open reading frame 58 Neighboring gene ybeY metalloendoribonuclease Neighboring gene pericentrin Neighboring gene uncharacterized LOC134483886

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Long non-coding RNA MCM3AP antisense RNA 1 silencing upregulates microRNA-24-3p to accelerate proliferation and migration of vascular endothelial cells in myocardial infarction rats by reducing EIF4G2. Chen K, et al. Cell Cycle, 2022 Apr. PMID 35113004, Free PMC Article
  2. A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication. Kuwahara K, et al. Blood, 2000 Apr 1. PMID 10733502
  3. The human TREX-2 complex is stably associated with the nuclear pore basket. Umlauf D, et al. J Cell Sci, 2013 Jun 15. PMID 23591820
  4. GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy. Singh SK, et al. Nat Commun, 2013. PMID 23652018, Free PMC Article
  5. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA MCM3AP antisense RNA 1 silencing upregulates microRNA-24-3p to accelerate proliferation and migration of vascular endothelial cells in myocardial infarction rats by reducing EIF4G2.
    Title: Long non-coding RNA MCM3AP antisense RNA 1 silencing upregulates microRNA-24-3p to accelerate proliferation and migration of vascular endothelial cells in myocardial infarction rats by reducing EIF4G2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H3 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in poly(A)+ mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in somatic hypermutation of immunoglobulin genes ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription export complex 2 IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription export complex 2 ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
germinal-center associated nuclear protein
Names
80 kDa MCM3-associated protein
minichromosome maintenance deficient 3 associated protein
NP_001099852.1
XP_006256356.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106382.1 → NP_001099852.1  germinal-center associated nuclear protein

    See identical proteins and their annotated locations for NP_001099852.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473988
    UniProtKB/TrEMBL
    A6JKC9, D3ZTA3
    Related
    ENSRNOP00000059693.1, ENSRNOT00000064637.2
    Conserved Domains (6) summary
    cd12443
    Location:433 → 501
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:684 → 908
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam13634
    Location:2 → 95
    Nucleoporin_FG; Nucleoporin FG repeat region
    pfam16766
    Location:1162 → 1231
    CID_GANP; Binding region of GANP to ENY2
    pfam16768
    Location:2 → 289
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam16769
    Location:1259 → 1904
    MCM3AP_GANP; MCM3AP domain of GANP

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    12127060..12164651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256294.5 → XP_006256356.1  germinal-center associated nuclear protein isoform X1

    See identical proteins and their annotated locations for XP_006256356.1

    UniProtKB/TrEMBL
    A0A0G2JV99, A6JKD0
    Conserved Domains (6) summary
    cd12443
    Location:433 → 501
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:684 → 908
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam13634
    Location:2 → 95
    Nucleoporin_FG; Nucleoporin FG repeat region
    pfam16766
    Location:1162 → 1231
    CID_GANP; Binding region of GANP to ENY2
    pfam16768
    Location:2 → 289
    NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
    pfam16769
    Location:1259 → 1971
    MCM3AP_GANP; MCM3AP domain of GANP
Nucleotide Protein Strain
Heading Accession and Version

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