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Aoc3 amine oxidase, copper containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29473, updated on 4-Jan-2025

Summary

Official Symbol
Aoc3provided by RGD
Official Full Name
amine oxidase, copper containing 3provided by RGD
Primary source
RGD:62058
See related
AllianceGenome:RGD:62058
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SSAO
Summary
Enables identical protein binding activity and primary methylamine oxidase activity. Involved in several processes, including eating behavior; leukocyte migration involved in inflammatory response; and positive regulation of D-glucose transmembrane transport. Located in extracellular space. Used to study aortic aneurysm; obesity; type 2 diabetes mellitus; and uveitis. Biomarker of intracranial aneurysm. Orthologous to human AOC3 (amine oxidase copper containing 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 470.0), Heart (RPKM 277.5) and 7 other tissues See more
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Genomic context

See Aoc3 in Genome Data Viewer
Location:
10q31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86773018..86780961)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86272757..86280702)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89251370..89259313)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 3 Neighboring gene amine oxidase, copper containing 2, pseudogene 1 Neighboring gene uncharacterized LOC134480877 Neighboring gene U1 spliceosomal RNA Neighboring gene glucose-6-phosphatase catalytic subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aliphatic amine oxidase activity  
enables calcium ion binding  
enables copper ion binding  
enables copper ion binding  
enables identical protein binding PubMed 
enables identical protein binding  
enables primary methylamine oxidase activity PubMed 
NOT enables primary methylamine oxidase activity  
enables primary methylamine oxidase activity  
enables primary methylamine oxidase activity PubMed 
enables protein heterodimerization activity  
enables quinone binding  
enables quinone binding PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus  
located_in Golgi apparatus  
located_in cell surface  
located_in cell surface PubMed 
located_in cytoplasm  
is_active_in early endosome  
located_in early endosome  
is_active_in endoplasmic reticulum  
located_in endoplasmic reticulum  
located_in extracellular space PubMed 
located_in membrane  
located_in membrane PubMed 
located_in microvillus  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane PubMed 

General protein information

Preferred Names
amine oxidase [copper-containing] 3
Names
VAP-1
VP97
copper amine oxidase
membrane primary amine oxidase
semicarbazide-sensitive amine oxidase
vascular adhesion protein 1
NP_113770.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031582.3NP_113770.2  amine oxidase [copper-containing] 3

    See identical proteins and their annotated locations for NP_113770.2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    O08590, Q497D2, Q5R1T5
    UniProtKB/TrEMBL
    A6HJB0
    Conserved Domains (4) summary
    COG3733
    Location:40722
    TynA; Cu2+-containing amine oxidase [Secondary metabolites biosynthesis, transport and catabolism]
    pfam01179
    Location:315721
    Cu_amine_oxid; Copper amine oxidase, enzyme domain
    pfam02727
    Location:66152
    Cu_amine_oxidN2; Copper amine oxidase, N2 domain
    pfam02728
    Location:169269
    Cu_amine_oxidN3; Copper amine oxidase, N3 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86773018..86780961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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