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Gpbp1 GC-rich promoter binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294734, updated on 13-Apr-2024

Summary

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Official Symbol
Gpbp1provided by RGD
Official Full Name
GC-rich promoter binding protein 1provided by RGD
Primary source
RGD:1305492
See related
Ensembl:ENSRNOG00000013002 AllianceGenome:RGD:1305492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305492
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Predicted to be active in nucleus. Orthologous to human GPBP1 (GC-rich promoter binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 340.7), Spleen (RPKM 330.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpbp1 in Genome Data Viewer
Location:
2q14
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (44756861..44824281, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (43023504..43091146, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (43002041..43070236, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate kinase 1 like 1 Neighboring gene actin, beta-like 2 Neighboring gene transfer RNA proline (anticodon AGG) 68 Neighboring gene uncharacterized LOC134485835

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. denDekker AD, et al. Cancer Res, 2012 Nov 15. PMID 22993404, Free PMC Article
  2. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. Hsu LC, et al. Mol Cell Biol, 2003 Dec. PMID 14612417, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vasculin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106410.2 → NP_001099880.1  vasculin isoform 1

    See identical proteins and their annotated locations for NP_001099880.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2K5K6, A6I5M9, F1M562, H9BFG8
    Related
    ENSRNOP00000073461.2, ENSRNOT00000090616.2
    Conserved Domains (1) summary
    pfam15337
    Location:398 → 477
    Vasculin; Vascular protein family Vasculin-like 1

  2. NM_001408813.1 → NP_001395742.1  vasculin isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    B1WBV9
    Related
    ENSRNOP00000038526.6, ENSRNOT00000036658.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    44756861..44824281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590710.2 → XP_017446199.1  vasculin isoform X4

    Conserved Domains (1) summary
    pfam15337
    Location:253 → 332
    Vasculin; Vascular protein family Vasculin-like 1

  2. XM_017590709.2 → XP_017446198.1  vasculin isoform X3

    Conserved Domains (1) summary
    pfam15337
    Location:273 → 352
    Vasculin; Vascular protein family Vasculin-like 1

  3. XM_063281510.1 → XP_063137580.1  vasculin isoform X2

    UniProtKB/TrEMBL
    B1WBV9

  4. XM_017590708.2 → XP_017446197.1  vasculin isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5K6, A6I5M9, F1M562, H9BFG8
    Conserved Domains (1) summary
    pfam15337
    Location:398 → 477
    Vasculin; Vascular protein family Vasculin-like 1

  5. XM_039101935.2 → XP_038957863.1  vasculin isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5K6, A6I5M9, F1M562, H9BFG8
    Conserved Domains (1) summary
    pfam15337
    Location:398 → 477
    Vasculin; Vascular protein family Vasculin-like 1

  6. XM_063281512.1 → XP_063137582.1  vasculin isoform X2

    UniProtKB/TrEMBL
    B1WBV9

  7. XM_063281513.1 → XP_063137583.1  vasculin isoform X2

    UniProtKB/TrEMBL
    B1WBV9

  8. XM_063281509.1 → XP_063137579.1  vasculin isoform X1

    UniProtKB/TrEMBL
    A0A0G2K5K6, A6I5M9, F1M562, H9BFG8

  9. XM_039101936.1 → XP_038957864.1  vasculin isoform X3

    Conserved Domains (1) summary
    pfam15337
    Location:273 → 352
    Vasculin; Vascular protein family Vasculin-like 1

  10. XM_063281514.1 → XP_063137584.1  vasculin isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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