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Gpx8 glutathione peroxidase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294744, updated on 3-Apr-2024

Summary

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Official Symbol
Gpx8provided by RGD
Official Full Name
glutathione peroxidase 8provided by RGD
Primary source
RGD:1307506
See related
AllianceGenome:RGD:1307506
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307506
Summary
Predicted to enable peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be integral component of membrane. Orthologous to human GPX8 (glutathione peroxidase 8 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 172.9), Adrenal (RPKM 114.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpx8 in Genome Data Viewer
Location:
2q14
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (46409646..46413401, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (44676448..44680042, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (44903337..44907046, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485839 Neighboring gene microRNA 449c Neighboring gene microRNA 449a Neighboring gene granzyme A Neighboring gene granzyme K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity. Mehmeti I, et al. Free Radic Biol Med, 2017 Nov. PMID 28751022
  2. Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation. Nguyen VD, et al. J Mol Biol, 2011 Feb 25. PMID 21215271
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns.
    Title: Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns.
  2. Endoplasmic reticulum (ER)-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting beta-cells against lipotoxicity by improving the ER antioxidative capacity.
    Title: ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect insulin-secreting INS-1E β-cells against lipotoxicity by improving the ER antioxidative capacity.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable glutathione peroxidase 8
NP_001099881.1
XP_038957865.1
XP_063137585.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106411.1 → NP_001099881.1  probable glutathione peroxidase 8

    See identical proteins and their annotated locations for NP_001099881.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473955
    UniProtKB/TrEMBL
    A6I5Q7, D3ZPW7
    Conserved Domains (1) summary
    TIGR02540
    Location:46 → 198
    gpx7; putative glutathione peroxidase Gpx7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    46409646..46413401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281515.1 → XP_063137585.1  probable glutathione peroxidase 8 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZP18

  2. XM_039101937.2 → XP_038957865.1  probable glutathione peroxidase 8 isoform X1

    Conserved Domains (1) summary
    cl00388
    Location:46 → 132
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein Strain
Heading Accession and Version

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