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Ranbp3l RAN binding protein 3-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 294789, updated on 2-May-2024

Summary

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Symbol
Ranbp3lprovided by RGD
Full Name
RAN binding protein 3-likeprovided by RGD
Primary source
RGD:1307559
See related
Ensembl:ENSRNOG00000052173 AllianceGenome:RGD:1307559
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307559
Summary
Predicted to enable SMAD binding activity. Predicted to be involved in mesenchymal cell differentiation involved in bone development; negative regulation of osteoblast differentiation; and positive regulation of myoblast differentiation. Orthologous to human RANBP3L (RAN binding protein 3 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 169.1), Brain (RPKM 36.1) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ranbp3l in Genome Data Viewer
Location:
2q16
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (59785070..59840338)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (58057887..58113158)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (58221773..58458072)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349962 Neighboring gene uncharacterized LOC134485718 Neighboring gene uncharacterized LOC120100736 Neighboring gene ribosomal protein S2, pseudogene 9 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene S-phase kinase associated protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation. Chen F, et al. Mol Cell Biol, 2015 May. PMID 25755279, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mesenchymal cell differentiation involved in bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAN binding protein 3-like; ran-binding protein 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    59785070..59840338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103548.2 → XP_038959476.1  ran-binding protein 3-like isoform X7

    UniProtKB/TrEMBL
    A0A096MJ81
    Conserved Domains (1) summary
    cd13180
    Location:290 → 405
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  2. XM_039103541.2 → XP_038959469.1  ran-binding protein 3-like isoform X1

    UniProtKB/TrEMBL
    A0A096MJ81
    Conserved Domains (1) summary
    cd13180
    Location:345 → 460
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  3. XM_039103542.2 → XP_038959470.1  ran-binding protein 3-like isoform X2

    UniProtKB/TrEMBL
    A0A096MJ81
    Conserved Domains (1) summary
    cd13180
    Location:344 → 459
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  4. XM_039103543.2 → XP_038959471.1  ran-binding protein 3-like isoform X3

    UniProtKB/TrEMBL
    A0A096MJ81
    Conserved Domains (1) summary
    cd13180
    Location:315 → 430
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  5. XM_039103544.2 → XP_038959472.1  ran-binding protein 3-like isoform X4

    UniProtKB/TrEMBL
    A0A096MJ81, A0A8I5YCF1
    Related
    ENSRNOP00000077562.1
    Conserved Domains (1) summary
    cd13180
    Location:314 → 429
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  6. XM_039103545.2 → XP_038959473.1  ran-binding protein 3-like isoform X5

    UniProtKB/TrEMBL
    A0A096MJ81
    Related
    ENSRNOP00000070782.2
    Conserved Domains (1) summary
    cd13180
    Location:290 → 405
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  7. XM_039103546.2 → XP_038959474.1  ran-binding protein 3-like isoform X6

    Conserved Domains (1) summary
    cd13180
    Location:73 → 188
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

  8. XM_039103547.2 → XP_038959475.1  ran-binding protein 3-like isoform X6

    Conserved Domains (1) summary
    cd13180
    Location:73 → 188
    RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
Nucleotide Protein Strain
Heading Accession and Version

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