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Slc3a1 solute carrier family 3 member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29484, updated on 4-Jan-2025

Summary

Official Symbol
Slc3a1provided by RGD
Official Full Name
solute carrier family 3 member 1provided by RGD
Primary source
RGD:3709
See related
EnsemblRapid:ENSRNOG00000007006 AllianceGenome:RGD:3709
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NBAT; rBAT
Summary
Predicted to enable protein heterodimerization activity. Involved in amino acid transport. Located in vacuolar membrane. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 7324.2) See more
Orthologs
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Genomic context

See Slc3a1 in Genome Data Viewer
Location:
6q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (15361037..15396695, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (9608169..9641881, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (8284937..8318649)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene calmodulin-lysine N-methyltransferase Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479091 Neighboring gene prolyl endopeptidase-like Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1B Neighboring gene cilia- and flagella-associated protein 251-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in L-cystine transport  
involved_in L-glutamate transmembrane transport  
involved_in amino acid transport  
involved_in amino acid transport PubMed 
involved_in aspartate transmembrane transport  
involved_in carbohydrate metabolic process  
involved_in gene expression  
Component Evidence Code Pubs
is_active_in apical plasma membrane  
located_in brush border membrane  
located_in vacuolar membrane PubMed 

General protein information

Preferred Names
amino acid transporter heavy chain SLC3A1
Names
D2
NAA-TR
b(0,+)-type amino acid transport protein
b(0,+)-type amino acid transporter-related heavy chain
neutral and basic amino acid transport protein rBAT
neutral and basic amino acid transporter protein
solute carrier family 3 (amino acid transporter heavy chain), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017216.1 → NP_058912.1  amino acid transporter heavy chain SLC3A1

    See identical proteins and their annotated locations for NP_058912.1

    Status: PROVISIONAL

    Source sequence(s)
    M77345
    UniProtKB/Swiss-Prot
    Q62672, Q64319
    UniProtKB/TrEMBL
    A6H9H4
    Related
    ENSRNOP00000009581.2, ENSRNOT00000009581.6
    Conserved Domains (1) summary
    cd11359
    Location:113 → 566
    AmyAc_SLC3A1; Alpha amylase catalytic domain found in Solute Carrier family 3 member 1 proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    15361037..15396695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261585.1 → XP_063117655.1  amino acid transporter heavy chain SLC3A1 isoform X1

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