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Tpd52 tumor protein D52 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294900, updated on 4-May-2024

Summary

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Official Symbol
Tpd52provided by RGD
Official Full Name
tumor protein D52provided by RGD
Primary source
RGD:1306767
See related
Ensembl:ENSRNOG00000011441 AllianceGenome:RGD:1306767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PrLZ; Crhsp-28
Summary
Predicted to enable calcium ion binding activity and protein homodimerization activity. Predicted to be involved in B cell differentiation. Predicted to act upstream of or within positive regulation of cell population proliferation. Predicted to be located in endoplasmic reticulum and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and glutamatergic synapse. Orthologous to human TPD52 (tumor protein D52). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Kidney (RPKM 179.8), Brain (RPKM 154.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tpd52 in Genome Data Viewer
Location:
2q23
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (94642514..94723442)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (92735365..92816079)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (94959732..95041277)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100771 Neighboring gene high mobility group protein B1-like Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene cytochrome c, somatic-like Neighboring gene uncharacterized protein C14orf119 homolog Neighboring gene small nucleolar RNA SNORA38

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells. Messenger SW, et al. Am J Physiol Gastrointest Liver Physiol, 2013 Sep 15. PMID 23868405, Free PMC Article
  2. Secretagogue-induced translocation of CRHSP-28 within an early apical endosomal compartment in acinar cells. Thomas DD, et al. Am J Physiol Gastrointest Liver Physiol, 2004 Jul. PMID 14977633
  3. Dietary and hormonal stimulation of rat exocrine pancreatic function regulates CRHSP-28 phosphorylation in vivo. Kaspar KM, et al. J Nutr, 2003 Oct. PMID 14519786
  4. Purification and identification of a 28-kDa calcium-regulated heat-stable protein. A novel secretagogue-regulated phosphoprotein in exocrine pancreas. Groblewski GE, et al. J Biol Chem, 1996 Dec 6. PMID 8940165
  5. Tumor protein D52 expression and Ca2+-dependent phosphorylation modulates lysosomal membrane protein trafficking to the plasma membrane. Thomas DD, et al. Am J Physiol Cell Physiol, 2010 Mar. PMID 20032513, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. binding of CRHSP-28 and annexin VI, together with their colocalization in the apical cytoplasm, is consistent with a role for these molecules in acinar cell membrane trafficking events that are essential for digestive enzyme secretion.
    Title: Identification of annexin VI as a Ca2+-sensitive CRHSP-28-binding protein in pancreatic acinar cells.
  2. data demonstrate that calcium-responsive heat stable protein-28(CRHSP-28 )phosphorylation occurs in vivo and can be used as a functional indicator of nutrient-driven pancreatic acinar cell activation
    Title: Dietary and hormonal stimulation of rat exocrine pancreatic function regulates CRHSP-28 phosphorylation in vivo.
  3. Calcium regulated heat stable protein-28 (CRHSP-28) accumulated on endosomes and positioned between zymogen granules below cell apex on CCK-8 stimulation. Present in acinar cells and regulated by secretagogue stimulation.
    Title: Secretagogue-induced translocation of CRHSP-28 within an early apical endosomal compartment in acinar cells.
  4. D52 regulates apical endolysosomal secretion in pancreatic acinar cells.
    Title: Tumor protein D52 controls trafficking of an apical endolysosomal secretory pathway in pancreatic acinar cells.
  5. Implicate both D52 expression and Ca(2+)-dependent phosphorylation at serine 136 in lysosomal membrane trafficking to and from the plasma membrane providing a novel Ca(2+)-sensitive pathway modulating the lysosome-like secretory pathway.
    Title: Tumor protein D52 expression and Ca2+-dependent phosphorylation modulates lysosomal membrane protein trafficking to the plasma membrane.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor protein D52
Names
calcium regulated heat stable protein-28
XP_006232205.3
XP_008759084.3
XP_038957892.2
XP_063137606.1
XP_063137607.1
XP_063137608.1
XP_063137609.1
XP_063137610.1
XP_063137611.1
XP_063137612.1
XP_063137613.1
XP_063137614.1
XP_063137615.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106421.3 → NP_001099891.3  tumor protein D52 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    Related
    ENSRNOP00000015327.6, ENSRNOT00000015327.7

  2. NM_001401807.2 → NP_001388736.2  tumor protein D52 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    Related
    ENSRNOP00000085840.1, ENSRNOT00000099506.1

  3. NM_001401808.2 → NP_001388737.2  tumor protein D52 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  4. NM_001429760.1 → NP_001416689.1  tumor protein D52 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  5. NM_001429761.1 → NP_001416690.1  tumor protein D52 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  6. NM_001429762.1 → NP_001416691.1  tumor protein D52 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  7. NM_001429763.1 → NP_001416692.1  tumor protein D52 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  8. NM_001429764.1 → NP_001416693.1  tumor protein D52 isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  9. NM_001429765.1 → NP_001416694.1  tumor protein D52 isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    94642514..94723442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281536.1 → XP_063137606.1  tumor protein D52 isoform X1

  2. XM_063281538.1 → XP_063137608.1  tumor protein D52 isoform X3

  3. XM_063281537.1 → XP_063137607.1  tumor protein D52 isoform X2

  4. XM_063281539.1 → XP_063137609.1  tumor protein D52 isoform X4

  5. XM_063281541.1 → XP_063137611.1  tumor protein D52 isoform X6

  6. XM_063281540.1 → XP_063137610.1  tumor protein D52 isoform X5

  7. XM_063281544.1 → XP_063137614.1  tumor protein D52 isoform X12

  8. XM_063281545.1 → XP_063137615.1  tumor protein D52 isoform X13

  9. XM_063281543.1 → XP_063137613.1  tumor protein D52 isoform X11

  10. XM_063281542.1 → XP_063137612.1  tumor protein D52 isoform X7

  11. XM_006232143.5 → XP_006232205.3  tumor protein D52 isoform X8

  12. XM_039101964.2 → XP_038957892.2  tumor protein D52 isoform X10

  13. XM_008760862.4 → XP_008759084.3  tumor protein D52 isoform X9

Nucleotide Protein Strain
Heading Accession and Version

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