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Adad1 adenosine deaminase domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294979, updated on 2-May-2024

Summary

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Official Symbol
Adad1provided by RGD
Official Full Name
adenosine deaminase domain containing 1provided by RGD
Primary source
RGD:1359309
See related
Ensembl:ENSRNOG00000017246 AllianceGenome:RGD:1359309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tenr
Summary
Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to act upstream of or within spermatid development. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ADAD1 (adenosine deaminase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 264.1) See more
Orthologs
human mouse all
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Genomic context

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See Adad1 in Genome Data Viewer
Location:
2q25
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (121872387..121935721)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (119948809..120005920)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (123790798..123848598)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7, pseudogene 22 Neighboring gene bridge-like lipid transfer protein family member 1 Neighboring gene THUMP domain containing 1, pseudogene 1 Neighboring gene interleukin 2 Neighboring gene interleukin 21 Neighboring gene centrin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Disruption of murine Tenr results in teratospermia and male infertility. Connolly CM, et al. Dev Biol, 2005 Feb 1. PMID 15649457
  2. Distribution of Tenr, an RNA-binding protein, in a lattice-like network within the spermatid nucleus in the mouse. Schumacher JM, et al. Biol Reprod, 1995 Jun. PMID 7543294
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94331, MGC124895

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT acts_upstream_of_or_within regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenosine deaminase domain-containing protein 1
Names
adenosine deaminase domain containing 1 (testis specific)
testis nuclear RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006977.2 → NP_001006978.2  adenosine deaminase domain-containing protein 1

    See identical proteins and their annotated locations for NP_001006978.2

    Status: VALIDATED

    Source sequence(s)
    BC083595, CV126304
    UniProtKB/Swiss-Prot
    Q3KR54
    Conserved Domains (2) summary
    cd19905
    Location:137 → 205
    DSRM_ADAD1; double-stranded RNA binding motif of adenosine deaminase domain-containing protein 1 (ADAD1) and similar proteins
    pfam02137
    Location:291 → 611
    A_deamin; Adenosine-deaminase (editase) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    121872387..121935721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281569.1 → XP_063137639.1  adenosine deaminase domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QBZ2

  2. XM_006232278.5 → XP_006232340.1  adenosine deaminase domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QBZ2
    Related
    ENSRNOP00000023282.5
    Conserved Domains (2) summary
    smart00358
    Location:139 → 204
    DSRM; Double-stranded RNA binding motif
    pfam02137
    Location:291 → 611
    A_deamin; Adenosine-deaminase (editase) domain

  3. XM_063281570.1 → XP_063137640.1  adenosine deaminase domain-containing protein 1 isoform X3

  4. XM_006232279.5 → XP_006232341.1  adenosine deaminase domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K1X9
    Conserved Domains (2) summary
    smart00358
    Location:112 → 177
    DSRM; Double-stranded RNA binding motif
    pfam02137
    Location:264 → 584
    A_deamin; Adenosine-deaminase (editase) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KR54.1 GenPept UniProtKB/Swiss-Prot:Q3KR54

Gene LinkOut

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