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Pctp phosphatidylcholine transfer protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 29510, updated on 2-May-2024

Summary

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Official Symbol
Pctpprovided by RGD
Official Full Name
phosphatidylcholine transfer proteinprovided by RGD
Primary source
RGD:3276
See related
Ensembl:ENSRNOG00000002425 AllianceGenome:RGD:3276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PC-TP; stARD2
Summary
Predicted to enable phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phospholipid transport. Predicted to act upstream of or within cholesterol metabolic process. Predicted to be located in cytosol. Orthologous to human PCTP (phosphatidylcholine transfer protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 243.0), Testes (RPKM 114.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pctp in Genome Data Viewer
Location:
10q26
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (75305999..75351919, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (74808887..74856260, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (77491445..77537268, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ankyrin-repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC134480856 Neighboring gene uncharacterized LOC120095174 Neighboring gene uncharacterized LOC103693415 Neighboring gene transmembrane protein 100 Neighboring gene small integral membrane protein 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and gene structure of rat phosphatidylcholine transfer protein, Pctp. Wu MK, et al. Gene, 1999 Jul 22. PMID 10415339
  2. Structure of human phosphatidylcholine transfer protein in complex with its ligand. Roderick SL, et al. Nat Struct Biol, 2002 Jul. PMID 12055623
  3. Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. Kang HW, et al. J Lipid Res, 2009 Nov. PMID 19502644, Free PMC Article
  4. cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene. Geijtenbeek TB, et al. Biochem J, 1996 May 15. PMID 8645232, Free PMC Article
  5. Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice. Wu MK, et al. Am J Physiol Gastrointest Liver Physiol, 2005 Sep. PMID 15845870

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylcholine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylcholine transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylcholine transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylcholine transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylcholine transporter activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipid transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylcholine transfer protein
Names
START domain-containing protein 2
stAR-related lipid transfer protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322798.1 → NP_001309727.1  phosphatidylcholine transfer protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    FN798834, JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6AL88
    Related
    ENSRNOP00000093865.1, ENSRNOT00000095165.1
    Conserved Domains (1) summary
    cl14643
    Location:1 → 98
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  2. NM_017225.3 → NP_058921.1  phosphatidylcholine transfer protein isoform 1

    See identical proteins and their annotated locations for NP_058921.1

    Status: VALIDATED

    Source sequence(s)
    FN798833, JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P53809, Q9Z2N9
    UniProtKB/TrEMBL
    A6HI08
    Related
    ENSRNOP00000003295.1, ENSRNOT00000003295.5
    Conserved Domains (1) summary
    cd08910
    Location:4 → 210
    START_STARD2-like; Lipid-binding START domain of mammalian STARD2 and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    75305999..75351919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085770.2 → XP_038941698.1  phosphatidylcholine transfer protein isoform X2

    UniProtKB/TrEMBL
    A6HI09
    Conserved Domains (1) summary
    cl14643
    Location:1 → 138
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  2. XM_008767983.3 → XP_008766205.1  phosphatidylcholine transfer protein isoform X2

    See identical proteins and their annotated locations for XP_008766205.1

    UniProtKB/TrEMBL
    A6HI09
    Conserved Domains (1) summary
    cl14643
    Location:1 → 138
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

  3. XM_006247125.4 → XP_006247187.1  phosphatidylcholine transfer protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZP06
    Related
    ENSRNOP00000079674.1
    Conserved Domains (1) summary
    cl14643
    Location:4 → 170
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53809.2 GenPept UniProtKB/Swiss-Prot:P53809

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