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Fhdc1 FH2 domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295161, updated on 5-Mar-2024

Summary

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Official Symbol
Fhdc1provided by RGD
Official Full Name
FH2 domain containing 1provided by RGD
Primary source
RGD:1311955
See related
Ensembl:ENSRNOG00000024594 AllianceGenome:RGD:1311955
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311955
Summary
Predicted to enable actin binding activity and microtubule binding activity. Predicted to be involved in Golgi ribbon formation; cilium assembly; and stress fiber assembly. Predicted to be located in Golgi apparatus; cilium; and cytoplasmic microtubule. Orthologous to human FHDC1 (FH2 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 93.6), Lung (RPKM 49.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fhdc1 in Genome Data Viewer
Location:
2q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (172088987..172127838, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (169790917..169829580, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (183450608..183487820, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 2 Neighboring gene uncharacterized LOC102550635 Neighboring gene uncharacterized LOC134485931 Neighboring gene uncharacterized LOC120100858 Neighboring gene ADP-ribosylation factor interacting protein 1 Neighboring gene tigger transposable element derived 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Actin- and microtubule-dependent regulation of Golgi morphology by FHDC1. Copeland SJ, et al. Mol Biol Cell, 2016 Jan 15. PMID 26564798, Free PMC Article
  2. INF1 is a novel microtubule-associated formin. Young KG, et al. Mol Biol Cell, 2008 Dec. PMID 18815276, Free PMC Article
  3. Actin-dependent regulation of cilia length by the inverted formin FHDC1. Copeland SJ, et al. Mol Biol Cell, 2018 Jul 1. PMID 29742020, Free PMC Article
  4. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi ribbon formation ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FH2 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106437.1 → NP_001099907.1  FH2 domain-containing protein 1

    See identical proteins and their annotated locations for NP_001099907.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473976
    UniProtKB/TrEMBL
    A6J5W7, D3ZL83
    Related
    ENSRNOP00000060810.2, ENSRNOT00000066477.4
    Conserved Domains (3) summary
    PTZ00449
    Location:559 → 760
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:733 → 1128
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam02181
    Location:93 → 457
    FH2; Formin Homology 2 Domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    172088987..172127838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102025.2 → XP_038957953.1  FH2 domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6J5W7, D3ZL83
    Conserved Domains (3) summary
    PTZ00449
    Location:559 → 760
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:733 → 1128
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam02181
    Location:93 → 457
    FH2; Formin Homology 2 Domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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