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Scamp1 secretory carrier membrane protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29521, updated on 2-May-2024

Summary

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Official Symbol
Scamp1provided by RGD
Official Full Name
secretory carrier membrane protein 1provided by RGD
Primary source
RGD:3625
See related
Ensembl:ENSRNOG00000061582 AllianceGenome:RGD:3625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein domain specific binding activity. Involved in endocytosis. Located in clathrin-coated vesicle. Is integral component of synaptic vesicle membrane. Orthologous to human SCAMP1 (secretory carrier membrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 263.0), Adrenal (RPKM 224.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Scamp1 in Genome Data Viewer
Location:
2q12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (27168863..27251637, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (25433958..25516734, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (23858021..23941128, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene LHFPL tetraspan subfamily member 2 Neighboring gene SNRPN upstream open reading frame, pseudogene 1 Neighboring gene small nuclear ribonucleoprotein polypeptide N, pseudogene 5 Neighboring gene adaptor related protein complex 3 subunit beta 1 Neighboring gene uncharacterized LOC108349922

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of fusion pore closure and compound exocytosis in neuroendocrine PC12 cells by SCAMP1. Zhang J, et al. Traffic, 2011 May. PMID 21272170, Free PMC Article
  2. SCAMP 37, a new marker within the general cell surface recycling system. Brand SH, et al. EMBO J, 1993 Oct. PMID 8404846, Free PMC Article
  3. Ubiquitously expressed secretory carrier membrane proteins (SCAMPs) 1-4 mark different pathways and exhibit limited constitutive trafficking to and from the cell surface. Castle A, et al. J Cell Sci, 2005 Aug 15. PMID 16105885
  4. Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice. Fernández-Chacón R, et al. J Biol Chem, 1999 Nov 12. PMID 10551807
  5. Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis. Liao H, et al. Am J Physiol Cell Physiol, 2008 Mar. PMID 18171723

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that SCAMP1's apparent dual role in facilitating dilation and closure of fusion pores implicates its function in exo-endocytic coupling and in the regulation of partial secretion.
    Title: Regulation of fusion pore closure and compound exocytosis in neuroendocrine PC12 cells by SCAMP1.
  2. SCAMP isoforms regulate membrane fusion and dense core vesicle exocytosis in neurons.
    Title: Nonredundant function of secretory carrier membrane protein isoforms in dense core vesicle exocytosis.
  3. SCAMPs travel between the cell surface and internal recycling systems, and form a mosaic with individual isoforms marking distinct pathways and functioning as trafficking machinery at sites of vesicle formation and fusion.
    Title: Ubiquitously expressed secretory carrier membrane proteins (SCAMPs) 1-4 mark different pathways and exhibit limited constitutive trafficking to and from the cell surface.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in terminal bouton HDA PubMed 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in zymogen granule membrane IEA
Inferred from Electronic Annotation
more info
  
located_in zymogen granule membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
secretory carrier-associated membrane protein 1
Names
SCAMP 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100636.1 → NP_001094106.1  secretory carrier-associated membrane protein 1

    See identical proteins and their annotated locations for NP_001094106.1

    Status: VALIDATED

    Source sequence(s)
    BC090322, CB740599, L22079
    UniProtKB/Swiss-Prot
    P56603
    UniProtKB/TrEMBL
    A0A0G2JY82
    Related
    ENSRNOP00000070553.2, ENSRNOT00000084044.2
    Conserved Domains (1) summary
    pfam04144
    Location:117 → 292
    SCAMP; SCAMP family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    27168863..27251637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102030.2 → XP_038957958.1  secretory carrier-associated membrane protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K1I6, A0A8I6ARE5, A6I4W5
    Related
    ENSRNOP00000071856.1
    Conserved Domains (1) summary
    pfam04144
    Location:117 → 258
    SCAMP; SCAMP family

  2. XM_039102028.2 → XP_038957956.1  secretory carrier-associated membrane protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A1V6, Q5D009
    Related
    ENSRNOP00000086247.1
    Conserved Domains (1) summary
    pfam04144
    Location:91 → 266
    SCAMP; SCAMP family

  3. XM_039102031.2 → XP_038957959.1  secretory carrier-associated membrane protein 1 isoform X3

    UniProtKB/TrEMBL
    Q5D009
    Conserved Domains (2) summary
    pfam04144
    Location:65 → 240
    SCAMP; SCAMP family
    cl03075
    Location:13 → 63
    GrpE; nucleotide exchange factor GrpE
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56603.1 GenPept UniProtKB/Swiss-Prot:P56603

Gene LinkOut

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