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Naxe NAD(P)HX epimerase [ Rattus norvegicus (Norway rat) ]

Gene ID: 295229, updated on 25-Apr-2024

Summary

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Official Symbol
Naxeprovided by RGD
Official Full Name
NAD(P)HX epimeraseprovided by RGD
Primary source
RGD:1304699
See related
Ensembl:ENSRNOG00000019201 AllianceGenome:RGD:1304699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AI-BP; Apoa1bp
Summary
Enables NADHX epimerase activity and NADPHX epimerase activity. Predicted to be involved in several processes, including membrane raft distribution; negative regulation of angiogenesis; and regulation of cholesterol efflux. Predicted to be located in several cellular components, including cell body; cilium; and extracellular space. Predicted to be active in mitochondrion. Orthologous to human NAXE (NAD(P)HX epimerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 164.4), Heart (RPKM 163.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (175816824..175818903, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (173518971..173521036, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187424319..187426410, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene hyaluronan and proteoglycan link protein 2 Neighboring gene G patch domain containing 4 Neighboring gene tetratricopeptide repeat domain 24 Neighboring gene IQ motif containing GTPase activating protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NAXE Mutations Disrupt the Cellular NAD(P)HX Repair System and Cause a Lethal Neurometabolic Disorder of Early Childhood. Kremer LS, et al. Am J Hum Genet, 2016 Oct 6. PMID 27616477, Free PMC Article
  2. Biochemical and structural characterization of apolipoprotein A-I binding protein, a novel phosphoprotein with a potential role in sperm capacitation. Jha KN, et al. Endocrinology, 2008 May. PMID 18202122, Free PMC Article
  3. Occurrence and subcellular distribution of the NADPHX repair system in mammals. Marbaix AY, et al. Biochem J, 2014 May 15. PMID 24611804
  4. Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. Ritter M, et al. Genomics, 2002 May. PMID 11991719
  5. Control of angiogenesis by AIBP-mediated cholesterol efflux. Fang L, et al. Nature, 2013 Jun 6. PMID 23719382, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NADHX epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADHX epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADPHX epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane raft distribution ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane raft distribution ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nicotinamide nucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NAD(P)H-hydrate epimerase
Names
apolipoprotein A-I-binding protein
NP_001386156.1
XP_063137676.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399227.1 → NP_001386156.1  NAD(P)H-hydrate epimerase precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    B0BNM1
    Related
    ENSRNOP00000025986.2, ENSRNOT00000025986.4
    Conserved Domains (1) summary
    PLN03049
    Location:50 → 281
    PLN03049; pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    175816824..175818903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281606.1 → XP_063137676.1  NAD(P)H-hydrate epimerase isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106440.1: Suppressed sequence

    Description
    NM_001106440.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0BNM1.1 GenPept UniProtKB/Swiss-Prot:B0BNM1

Gene LinkOut

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