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Ube2q1 ubiquitin conjugating enzyme E2 Q1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295252, updated on 5-Mar-2024

Summary

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Official Symbol
Ube2q1provided by RGD
Official Full Name
ubiquitin conjugating enzyme E2 Q1provided by RGD
Primary source
RGD:1305305
See related
Ensembl:ENSRNOG00000020791 AllianceGenome:RGD:1305305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ube2q
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to act upstream of or within several processes, including embryo implantation; prolactin secretion; and suckling behavior. Predicted to be active in nucleus. Orthologous to human UBE2Q1 (ubiquitin conjugating enzyme E2 Q1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 184.9), Kidney (RPKM 168.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ube2q1 in Genome Data Viewer
Location:
2q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177496480..177505631)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175198793..175209152)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189106039..189115110)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene adenosine deaminase, RNA-specific Neighboring gene cholinergic receptor nicotinic beta 2 subunit Neighboring gene uncharacterized LOC103691620 Neighboring gene Src homology 2 domain containing E Neighboring gene interleukin 6 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Downregulation of UBE2Q1 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury. Wan C, et al. J Neurosci Res, 2014 Jan. PMID 24166684
  2. Embryo implantation failure and other reproductive defects in Ube2q1-deficient female mice. Grzmil P, et al. Reproduction, 2013 Jan. PMID 23108111
  3. Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells. Wassler MJ, et al. Stem Cells, 2008 Aug. PMID 18511602
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UBE2Q1 might play an important role in the neuropathological process of traumatic brain injury through modulating p53 signaling.
    Title: Downregulation of UBE2Q1 is associated with neuronal apoptosis in rat brain cortex following traumatic brain injury.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryo implantation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mating behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within prolactin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within reproductive system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within suckling behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 Q1
Names
ubiquitin-conjugating enzyme E2Q (putative) 1
ubiquitin-conjugating enzyme E2Q family member 1
NP_001099918.1
XP_038957972.1
XP_063137686.1
XP_063137687.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106448.2 → NP_001099918.1  ubiquitin-conjugating enzyme E2 Q1

    See identical proteins and their annotated locations for NP_001099918.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166534
    UniProtKB/TrEMBL
    B2GV55, F7FI50
    Related
    ENSRNOP00000028210.5, ENSRNOT00000028210.6
    Conserved Domains (1) summary
    cd00195
    Location:253 → 409
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    177496480..177505631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281616.1 → XP_063137686.1  ubiquitin-conjugating enzyme E2 Q1 isoform X1

  2. XM_039102044.2 → XP_038957972.1  ubiquitin-conjugating enzyme E2 Q1 isoform X2

    Conserved Domains (1) summary
    cl00154
    Location:253 → 358
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. XM_063281617.1 → XP_063137687.1  ubiquitin-conjugating enzyme E2 Q1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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