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Rbm8a RNA binding motif protein 8A [ Rattus norvegicus (Norway rat) ]

Gene ID: 295284, updated on 13-Apr-2024

Summary

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Official Symbol
Rbm8aprovided by RGD
Official Full Name
RNA binding motif protein 8Aprovided by RGD
Primary source
RGD:1310099
See related
Ensembl:ENSRNOG00000021215 AllianceGenome:RGD:1310099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rbm8
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and regulation of alternative mRNA splicing, via spliceosome. Located in dendrite; neuronal cell body; and nucleus. Human ortholog(s) of this gene implicated in thrombocytopenia-absent radius syndrome. Orthologous to human RBM8A (RNA binding motif protein 8A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 39.8), Spleen (RPKM 39.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186854018..186856802)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184165189..184167959)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198755261..198758028)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 34A Neighboring gene limb and CNS expressed 1 like Neighboring gene high mobility group protein B1-like Neighboring gene peroxisomal biogenesis factor 11 beta Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134485661

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RNA splicing capability of live neuronal dendrites. Glanzer J, et al. Proc Natl Acad Sci U S A, 2005 Nov 15. PMID 16275927, Free PMC Article
  2. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Kataoka N, et al. Mol Cell, 2000 Sep. PMID 11030346
  3. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. Diem MD, et al. Nat Struct Mol Biol, 2007 Dec. PMID 18026120
  4. The ever-increasing complexities of the exon junction complex. Tange TØ, et al. Curr Opin Cell Biol, 2004 Jun. PMID 15145352
  5. The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons. Monshausen M, et al. Neuromolecular Med, 2004. PMID 15970630

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 1 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type catalytic step 1 spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exon-exon junction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exon-exon junction complex ISO
Inferred from Sequence Orthology
more info
  
part_of exon-exon junction subcomplex mago-y14 ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein 8A
Names
RNA binding motif protein 8
ribonucleoprotein RBM8A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271138.1 → NP_001258067.1  RNA-binding protein 8A

    See identical proteins and their annotated locations for NP_001258067.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q27W01
    UniProtKB/TrEMBL
    A6K380
    Related
    ENSRNOP00000028807.4, ENSRNOT00000028807.8
    Conserved Domains (1) summary
    cd12324
    Location:67 → 151
    RRM_RBM8; RNA recognition motif (RRM) found in RNA-binding protein RBM8A, RBM8B nd similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    186854018..186856802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232956.5 → XP_006233018.1  RNA-binding protein 8A isoform X1

    See identical proteins and their annotated locations for XP_006233018.1

    Conserved Domains (1) summary
    cd12324
    Location:66 → 150
    RRM_RBM8; RNA recognition motif (RRM) found in RNA-binding protein RBM8A, RBM8B nd similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27W01.1 GenPept UniProtKB/Swiss-Prot:Q27W01

Gene LinkOut

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