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Ndst3 N-deacetylase and N-sulfotransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295430, updated on 13-Apr-2024

Summary

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Official Symbol
Ndst3provided by RGD
Official Full Name
N-deacetylase and N-sulfotransferase 3provided by RGD
Primary source
RGD:1310960
See related
Ensembl:ENSRNOG00000015781 AllianceGenome:RGD:1310960
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and heparan sulfate N-deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Orthologous to human NDST3 (N-deacetylase and N-sulfotransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 68.8), Spleen (RPKM 7.3) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Ndst3 in Genome Data Viewer
Location:
2q42
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (214386804..214552739, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (211702728..211868159, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (227736491..227903657, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene serine protease 12 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene ETS variant transcription factor 5, pseudogene 4 Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. Aikawa J, et al. J Biol Chem, 1999 Jan 29. PMID 9915799
  2. Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. Aikawa J, et al. J Biol Chem, 2001 Feb 23. PMID 11087757
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetylglucosamine deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine N-sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables heparan sulfate N-deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
Names
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
N-deacetylase/N-sulfotransferase 3
NP_001178645.1
XP_006233330.1
XP_017446275.1
XP_038958023.1
XP_038958024.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191716.1 → NP_001178645.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

    See identical proteins and their annotated locations for NP_001178645.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6HVJ7, D4ABE3
    Related
    ENSRNOP00000021335.1, ENSRNOT00000021335.4
    Conserved Domains (2) summary
    pfam00685
    Location:595 → 846
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:20 → 506
    HSNSD; heparan sulfate-N-deacetylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    214386804..214552739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590786.3 → XP_017446275.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X1

    UniProtKB/TrEMBL
    A6HVJ7, D4ABE3
    Conserved Domains (2) summary
    pfam00685
    Location:595 → 846
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:20 → 506
    HSNSD; heparan sulfate-N-deacetylase

  2. XM_006233268.4 → XP_006233330.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006233330.1

    UniProtKB/TrEMBL
    A6HVJ7, D4ABE3
    Conserved Domains (2) summary
    pfam00685
    Location:595 → 846
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:20 → 506
    HSNSD; heparan sulfate-N-deacetylase

  3. XM_039102095.1 → XP_038958023.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X2

    Conserved Domains (1) summary
    pfam12062
    Location:20 → 506
    HSNSD; heparan sulfate-N-deacetylase

  4. XM_039102096.2 → XP_038958024.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X3

    Conserved Domains (1) summary
    pfam12062
    Location:20 → 506
    HSNSD; heparan sulfate-N-deacetylase
Nucleotide Protein Strain
Heading Accession and Version

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