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Lsamp limbic system-associated membrane protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 29561, updated on 2-May-2024

Summary

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Official Symbol
Lsampprovided by RGD
Official Full Name
limbic system-associated membrane proteinprovided by RGD
Primary source
RGD:71102
See related
Ensembl:ENSRNOG00000031852 AllianceGenome:RGD:71102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in cell adhesion. Predicted to act upstream of or within locomotory exploration behavior. Predicted to be located in cytosol. Orthologous to human LSAMP (limbic system associated membrane protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 356.2), Heart (RPKM 127.5) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lsamp in Genome Data Viewer
Location:
11q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (72053285..74223019, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (58547533..60717328, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (58795884..59442772, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481071 Neighboring gene growth associated protein 43 Neighboring gene small nucleolar RNA SNORA32 Neighboring gene uncharacterized LOC108352336 Neighboring gene large ribosomal subunit protein uL6-like Neighboring gene uncharacterized LOC134481073 Neighboring gene peptidylprolyl isomerase D, pseudogene 8 Neighboring gene uncharacterized LOC134481004 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rats with low exploratory activity in the elevated plus-maze have the increased expression of limbic system-associated membrane protein gene in the periaqueductal grey. Nelovkov A, et al. Neurosci Lett, 2003 Dec 11. PMID 14625014
  2. The limbic system-associated membrane protein is an Ig superfamily member that mediates selective neuronal growth and axon targeting. Pimenta AF, et al. Neuron, 1995 Aug. PMID 7646886
  3. Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments. Catania EH, et al. Behav Brain Res, 2008 Apr 9. PMID 18199495, Free PMC Article
  4. Characterization of the genomic structure of the mouse limbic system-associated membrane protein (Lsamp) gene. Pimenta AF, et al. Genomics, 2004 May. PMID 15081109
  5. Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons. Sanz RL, et al. Sci Rep, 2017 Aug 11. PMID 28801670, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neurotrimin and LSAMP were identified as ADAM10 substrates that are shed from the cell surface of dorsal root ganglion (DRGs) neurons. Overexpression of LSAMP and NTM suppresses outgrowth from DRG neurons.
    Title: Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons.
  2. It is likely that LSAMP plays a role in the regulation of exploratory behavior of rats in the novel aversive environment.
    Title: Rats with low exploratory activity in the elevated plus-maze have the increased expression of limbic system-associated membrane protein gene in the periaqueductal grey.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105298

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within locomotory exploration behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
limbic system-associated membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414997.1 → NP_001401926.1  limbic system-associated membrane protein isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

  2. NM_017242.3 → NP_058938.1  limbic system-associated membrane protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_058938.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q62813, Q6VUH9
    UniProtKB/TrEMBL
    A0A8I5ZZN4, A6IR42
    Related
    ENSRNOP00000085583.1, ENSRNOT00000100246.1
    Conserved Domains (3) summary
    pfam13927
    Location:218 → 294
    Ig_3; Immunoglobulin domain
    cd00096
    Location:235 → 239
    Ig; Ig strand B [structural motif]
    cl11960
    Location:38 → 128
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    72053285..74223019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088255.2 → XP_038944183.1  limbic system-associated membrane protein isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHY3, A0A8I5ZZN4
    Related
    ENSRNOP00000047121.4
    Conserved Domains (3) summary
    pfam13927
    Location:235 → 311
    Ig_3; Immunoglobulin domain
    cd00096
    Location:252 → 256
    Ig; Ig strand B [structural motif]
    cl11960
    Location:55 → 145
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62813.1 GenPept UniProtKB/Swiss-Prot:Q62813

Gene LinkOut

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