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Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295690, updated on 2-May-2024

Summary

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Official Symbol
Dnajc10provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member C10provided by RGD
Primary source
RGD:1307813
See related
Ensembl:ENSRNOG00000006803 AllianceGenome:RGD:1307813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATPase binding activity; Hsp70 protein binding activity; and oxidoreductase activity, acting on a sulfur group of donors. Predicted to be involved in several processes, including positive regulation of ATPase activity; protein folding in endoplasmic reticulum; and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum lumen. Predicted to be part of endoplasmic reticulum chaperone complex. Orthologous to human DNAJC10 (DnaJ heat shock protein family (Hsp40) member C10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 337.6), Brain (RPKM 285.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajc10 in Genome Data Viewer
Location:
3q24
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (85636890..85679620)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (65232031..65272732)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (67538289..67578308)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 1A Neighboring gene uncharacterized LOC134486399 Neighboring gene uncharacterized LOC103691836 Neighboring gene uncharacterized LOC134486398 Neighboring gene frizzled-related protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ERdj5 sensitizes neuroblastoma cells to endoplasmic reticulum stress-induced apoptosis. Thomas CG, et al. J Biol Chem, 2009 Mar 6. PMID 19122239
  2. ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor. Oka OB, et al. Mol Cell, 2013 Jun 27. PMID 23769672, Free PMC Article
  3. ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER. Ushioda R, et al. Science, 2008 Jul 25. PMID 18653895
  4. Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5. Hagiwara M, et al. Mol Cell, 2011 Feb 18. PMID 21329881
  5. JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs. Hosoda A, et al. J Biol Chem, 2003 Jan 24. PMID 12446677

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables disulfide oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables disulfide oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-disulfide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in IRE1-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of endoplasmic reticulum chaperone complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 10
Names
DnaJ (Hsp40) homolog, subfamily C, member 10
NP_001099956.2
XP_038960426.1
XP_063139350.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106486.2 → NP_001099956.2  dnaJ homolog subfamily C member 10 precursor

    See identical proteins and their annotated locations for NP_001099956.2

    Status: VALIDATED

    Source sequence(s)
    BC100105, CA338978, CA510153, CB577930, CX570839, DY315949
    UniProtKB/Swiss-Prot
    Q498R3
    UniProtKB/TrEMBL
    A0A8I5ZQ34
    Related
    ENSRNOP00000009839.4, ENSRNOT00000009839.5
    Conserved Domains (5) summary
    COG0484
    Location:34 → 132
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cd03003
    Location:129 → 229
    PDI_a_ERdj5_N; PDIa family, N-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is comprised of the first TRX domain of ERdj5 located after the ...
    cd03004
    Location:556 → 663
    PDI_a_ERdj5_C; PDIa family, C-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is composed of the three TRX domains located at the C-terminal ...
    TIGR01130
    Location:130 → 551
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    pfam00226
    Location:35 → 97
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    85636890..85679620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104498.2 → XP_038960426.1  dnaJ homolog subfamily C member 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQ34, A0A8I6AIP1
    Related
    ENSRNOP00000092816.1
    Conserved Domains (4) summary
    COG0484
    Location:34 → 132
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cd03003
    Location:129 → 229
    PDI_a_ERdj5_N; PDIa family, N-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is comprised of the first TRX domain of ERdj5 located after the ...
    cd03004
    Location:556 → 663
    PDI_a_ERdj5_C; PDIa family, C-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is composed of the three TRX domains located at the C-terminal ...
    TIGR01130
    Location:130 → 551
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  2. XM_063283280.1 → XP_063139350.1  dnaJ homolog subfamily C member 10 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q498R3.2 GenPept UniProtKB/Swiss-Prot:Q498R3

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