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Ehf ets homologous factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 295965, updated on 5-Mar-2024

Summary

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Official Symbol
Ehfprovided by RGD
Official Full Name
ets homologous factorprovided by RGD
Primary source
RGD:1310282
See related
Ensembl:ENSRNOG00000007484 AllianceGenome:RGD:1310282
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epithelial cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in nucleus. Used to study abdominal aortic aneurysm. Orthologous to human EHF (ETS homologous factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 48.1), Kidney (RPKM 46.8) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q32
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (110094770..110134991, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (89639845..89680061, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (93176257..93216484, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene APAF1 interacting protein Neighboring gene RNA, U6 small nuclear 434 Neighboring gene uncharacterized LOC102548892 Neighboring gene E74 like ETS transcription factor 5 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene catalase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors. Nakashima H, et al. Circulation, 2004 Jan 6. PMID 14662712
  2. ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. Kas K, et al. J Biol Chem, 2000 Jan 28. PMID 10644770
  3. ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites. Lim JH, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17027647
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ETS homologous factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106493.2 → NP_001099963.1  ETS homologous factor

    See identical proteins and their annotated locations for NP_001099963.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166742
    UniProtKB/TrEMBL
    A0A8I5ZQ62, B2RYD8, F7F464
    Related
    ENSRNOP00000010580.4, ENSRNOT00000010580.7
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    110094770..110134991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234641.5 → XP_006234703.1  ETS homologous factor isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQ62
    Conserved Domains (2) summary
    smart00413
    Location:205 → 292
    ETS; erythroblast transformation specific domain
    cl15755
    Location:39 → 116
    SAM_superfamily; SAM (Sterile alpha motif )

  2. XM_039104530.2 → XP_038960458.1  ETS homologous factor isoform X2

    UniProtKB/TrEMBL
    A6HNR1
    Conserved Domains (2) summary
    smart00413
    Location:119 → 206
    ETS; erythroblast transformation specific domain
    cl15755
    Location:1 → 29
    SAM_superfamily; SAM (Sterile alpha motif )

RNA

  1. XR_005501812.2 RNA Sequence

  2. XR_005501811.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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