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Fahd2a fumarylacetoacetate hydrolase domain containing 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 296131, updated on 13-Apr-2024

Summary

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Official Symbol
Fahd2aprovided by RGD
Official Full Name
fumarylacetoacetate hydrolase domain containing 2Aprovided by RGD
Primary source
RGD:1563674
See related
Ensembl:ENSRNOG00000013974 AllianceGenome:RGD:1563674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fahd2; RGD1563674
Summary
Predicted to enable hydro-lyase activity. Orthologous to human FAHD2A (fumarylacetoacetate hydrolase domain containing 2A) and FAHD2B (fumarylacetoacetate hydrolase domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 512.7), Adrenal (RPKM 198.2) and 9 other tissues See more
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Genomic context

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Location:
3q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (135110480..135118653, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (114657176..114665349, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (120003215..120011392, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene adrenoceptor alpha 2B Neighboring gene glycerol-3-phosphate acyltransferase 2, mitochondrial Neighboring gene ribosomal protein L9, pseudogene 28 Neighboring gene potassium voltage-gated channel interacting protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fumarylacetoacetate hydrolase domain-containing protein 2
NP_001128306.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134834.2 → NP_001128306.1  fumarylacetoacetate hydrolase domain-containing protein 2

    See identical proteins and their annotated locations for NP_001128306.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    B2RYW9
    UniProtKB/TrEMBL
    A6HQ16
    Related
    ENSRNOP00000079379.1, ENSRNOT00000109233.1
    Conserved Domains (2) summary
    COG0179
    Location:48 → 313
    MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]
    pfam01557
    Location:109 → 312
    FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    135110480..135118653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RYW9.1 GenPept UniProtKB/Swiss-Prot:B2RYW9

Gene LinkOut

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