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Tgm6 transglutaminase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296152, updated on 5-Mar-2024

Summary

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Official Symbol
Tgm6provided by RGD
Official Full Name
transglutaminase 6provided by RGD
Primary source
RGD:1565348
See related
Ensembl:ENSRNOG00000006830 AllianceGenome:RGD:1565348
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565348
Summary
Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 35. Orthologous to human TGM6 (transglutaminase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 5.4), Thymus (RPKM 1.2) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tgm6 in Genome Data Viewer
Location:
3q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (137771368..137809000)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117324268..117355674)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (122644183..122680054)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nuclear ribonucleoprotein polypeptides B and B1 Neighboring gene small nucleolar RNA U3 Neighboring gene transmembrane channel-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Spinocerebellar ataxia 35: novel mutations in TGM6 with clinical and genetic characterization. Guo YC, et al. Neurology, 2014 Oct 21. PMID 25253745
  2. Identification of a highly reactive substrate peptide for transglutaminase 6 and its use in detecting transglutaminase activity in the skin epidermis. Fukui M, et al. FEBS J, 2013 Mar. PMID 23331848
  3. Spinocerebellar ataxia type 35 (SCA35)-associated transglutaminase 6 mutants sensitize cells to apoptosis. Guan WJ, et al. Biochem Biophys Res Commun, 2013 Jan 11. PMID 23206699
  4. Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia. Nibbeling EAR, et al. Brain, 2017 Nov 1. PMID 29053796
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-glutamine gamma-glutamyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glutamine gamma-glutamyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptide cross-linking IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein-glutamine gamma-glutamyltransferase 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    137771368..137809000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284796.1 → XP_063140866.1  protein-glutamine gamma-glutamyltransferase 6

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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