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Ralgapa2 Ral GTPase activating protein catalytic subunit alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296211, updated on 13-Apr-2024

Summary

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Official Symbol
Ralgapa2provided by RGD
Official Full Name
Ral GTPase activating protein catalytic subunit alpha 2provided by RGD
Primary source
RGD:1308023
See related
Ensembl:ENSRNOG00000036964 AllianceGenome:RGD:1308023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p220; AS250; RGD1308023
Summary
Enables GTPase activator activity and protein heterodimerization activity. Involved in activation of GTPase activity. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 151.4), Kidney (RPKM 146.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ralgapa2 in Genome Data Viewer
Location:
3q41
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (154112005..154392070, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (133658725..133938821, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (140451850..140728305, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 61 Neighboring gene eukaryotic translation initiation factor 4A1, pseudogene 3 Neighboring gene uncharacterized LOC134486169 Neighboring gene uncharacterized LOC108350486 Neighboring gene INSM transcriptional repressor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108350487 Neighboring gene Bcl2 like 12, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. Gridley S, et al. Cell Signal, 2006 Oct. PMID 16490346
  2. Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. Shirakawa R, et al. J Biol Chem, 2009 Aug 7. PMID 19520869, Free PMC Article
  3. A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Chen XW, et al. Mol Biol Cell, 2011 Jan 1. PMID 21148297, Free PMC Article
  4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  5. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Ral protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of exocyst localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ral GTPase-activating protein subunit alpha-2
Names
250 kDa substrate of Akt
Ral GTPase activating protein catalytic alpha subunit 2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
Ral GTPase-activating protein alpha subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421313.1 → NP_001408242.1  ral GTPase-activating protein subunit alpha-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6G4U3
    Related
    ENSRNOP00000080653.1, ENSRNOT00000094218.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    154112005..154392070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283347.1 → XP_063139417.1  ral GTPase-activating protein subunit alpha-2 isoform X2

  2. XM_017592238.3 → XP_017447727.2  ral GTPase-activating protein subunit alpha-2 isoform X1

    UniProtKB/Swiss-Prot
    P86411
    Related
    ENSRNOP00000015637.8
    Conserved Domains (1) summary
    pfam02145
    Location:1765 → 1937
    Rap_GAP; Rap/ran-GAP

  3. XM_063283348.1 → XP_063139418.1  ral GTPase-activating protein subunit alpha-2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AGG2

  4. XM_063283349.1 → XP_063139419.1  ral GTPase-activating protein subunit alpha-2 isoform X4

  5. XM_063283350.1 → XP_063139420.1  ral GTPase-activating protein subunit alpha-2 isoform X5

  6. XM_063283352.1 → XP_063139422.1  ral GTPase-activating protein subunit alpha-2 isoform X9

  7. XM_063283353.1 → XP_063139423.1  ral GTPase-activating protein subunit alpha-2 isoform X10

  8. XM_039106622.2 → XP_038962550.1  ral GTPase-activating protein subunit alpha-2 isoform X6

  9. XM_039106624.2 → XP_038962552.1  ral GTPase-activating protein subunit alpha-2 isoform X8

  10. XM_039106623.2 → XP_038962551.1  ral GTPase-activating protein subunit alpha-2 isoform X7

RNA

  1. XR_005502529.2 RNA Sequence

  2. XR_005502528.2 RNA Sequence

  3. XR_005502527.2 RNA Sequence

  4. XR_010064588.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P86411.1 GenPept UniProtKB/Swiss-Prot:P86411

Gene LinkOut

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Chemical Information
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