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Gria2 glutamate ionotropic receptor AMPA type subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29627, updated on 17-Dec-2024

Summary

Official Symbol
Gria2provided by RGD
Official Full Name
glutamate ionotropic receptor AMPA type subunit 2provided by RGD
Primary source
RGD:61862
See related
EnsemblRapid:ENSRNOG00000054204 AllianceGenome:RGD:61862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GluA2; GluR2; gluR-B; GluR-K2
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca(2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward (RPKM 706.1) See more
Orthologs
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Genomic context

See Gria2 in Genome Data Viewer
Location:
2q33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (168247490..168367616, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (165949379..166069510, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (179584302..179704629, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene golgi associated kinase 1B Neighboring gene Parkinsonism associated deglycase, pseudogene 3 Neighboring gene small nucleolar RNA SNORA9 Neighboring gene microRNA 2985 Neighboring gene uncharacterized LOC134485927 Neighboring gene glycine receptor, beta Neighboring gene RNA, U7 small nuclear 62 Neighboring gene platelet derived growth factor C

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 35
Function Evidence Code Pubs
enables AMPA glutamate receptor activity  
enables AMPA glutamate receptor activity PubMed 
enables AMPA glutamate receptor activity PubMed 
enables PDZ domain binding PubMed 
enables PDZ domain binding PubMed 
enables SNARE binding PubMed 
enables amyloid-beta binding PubMed 
enables cytoskeletal protein binding PubMed 
enables extracellular ligand-gated monoatomic ion channel activity PubMed 
enables extracellularly glutamate-gated ion channel activity  
enables glutamate receptor binding PubMed 
enables glutamate-gated calcium ion channel activity PubMed 
enables glutamate-gated receptor activity PubMed 
enables glutamate-gated receptor activity  
enables glutamate-gated receptor activity  
enables glutamate-gated receptor activity PubMed 
enables identical protein binding PubMed 
enables immunoglobulin binding PubMed 
enables ionotropic glutamate receptor binding PubMed 
enables kainate selective glutamate receptor activity PubMed 
enables ligand-gated monoatomic cation channel activity PubMed 
enables ligand-gated monoatomic ion channel activity  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
enables protein binding PubMed 
enables protein kinase binding PubMed 
enables protein-containing complex binding PubMed 
enables scaffold protein binding PubMed 
enables signaling receptor activity PubMed 
enables signaling receptor activity  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
Items 1 - 25 of 35
Process Evidence Code Pubs
involved_in calcium-mediated signaling  
involved_in cellular response to brain-derived neurotrophic factor stimulus PubMed 
involved_in cellular response to glycine PubMed 
involved_in cerebral cortex development PubMed 
involved_in chemical synaptic transmission PubMed 
acts_upstream_of_or_within chemical synaptic transmission  
involved_in establishment of protein localization PubMed 
involved_in excitatory postsynaptic potential  
involved_in ionotropic glutamate receptor signaling pathway  
involved_in ionotropic glutamate receptor signaling pathway  
involved_in ionotropic glutamate receptor signaling pathway  
involved_in modulation of chemical synaptic transmission  
involved_in monoatomic cation transmembrane transport  
involved_in monoatomic ion transmembrane transport  
involved_in positive regulation of synaptic transmission PubMed 
involved_in protein tetramerization PubMed 
involved_in receptor internalization PubMed 
involved_in regulation of presynaptic membrane potential  
involved_in regulation of receptor recycling PubMed 
involved_in regulation of synaptic transmission, glutamatergic PubMed 
involved_in response to fungicide PubMed 
involved_in response to lithium ion PubMed 
involved_in synaptic transmission, glutamatergic  
Items 1 - 20 of 56
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex  
part_of AMPA glutamate receptor complex PubMed 
part_of AMPA glutamate receptor complex  
is_active_in Schaffer collateral - CA1 synapse PubMed 
is_active_in Schaffer collateral - CA1 synapse PubMed 
is_active_in Schaffer collateral - CA1 synapse  
located_in asymmetric synapse PubMed 
located_in axon PubMed 
located_in cell surface PubMed 
located_in dendrite PubMed 
located_in dendrite  
located_in dendrite cytoplasm PubMed 
located_in dendrite membrane PubMed 
located_in dendritic shaft PubMed 
is_active_in dendritic spine  
located_in dendritic spine PubMed 
located_in dendritic spine head PubMed 
located_in dendritic spine neck PubMed 
located_in endoplasmic reticulum  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
located_in growth cone PubMed 
part_of ionotropic glutamate receptor complex PubMed 
located_in membrane  
located_in neuron projection  
located_in neuronal cell body PubMed 
located_in perikaryon PubMed 
located_in perisynaptic space  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
located_in postsynaptic density PubMed 
located_in postsynaptic density  
is_active_in postsynaptic density membrane  
is_active_in postsynaptic density membrane PubMed 
located_in postsynaptic density membrane  
is_active_in postsynaptic density membrane  
located_in postsynaptic density membrane  
is_active_in postsynaptic membrane PubMed 
located_in postsynaptic membrane  
located_in presynapse PubMed 
is_active_in presynaptic active zone membrane PubMed 
is_active_in presynaptic membrane PubMed 
located_in presynaptic membrane PubMed 
part_of protein-containing complex PubMed 
part_of protein-containing complex PubMed 
located_in somatodendritic compartment  
located_in spine synapse PubMed 
located_in synapse PubMed 
located_in synapse  
located_in synaptic membrane  
located_in synaptic vesicle  
located_in synaptic vesicle membrane PubMed 
located_in synaptic vesicle membrane  
located_in terminal bouton PubMed 
Items 1 - 20 of 56

General protein information

Preferred Names
glutamate receptor 2
Names
AMPA-selective glutamate receptor 2
glutamate receptor B
glutamate receptor, ionotropic, AMPA 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083811.1NP_001077280.1  glutamate receptor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001077280.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to transcript variant 1, and encodes an isoform (2, also known as the flop isoform) that is the same length as isoform 1, but with few amino acid differences. RNA editing changes Gln607Arg (CAG->CGG) and Arg764Gly (AGA->GGA).
    Source sequence(s)
    AF164344, CO400088, JAXUCZ010000002, M38061, M85035
    UniProtKB/Swiss-Prot
    P19491, Q9R174
    Related
    ENSRNOP00000069094.2, ENSRNOT00000077941.3
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
  2. NM_017261.2NP_058957.1  glutamate receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_058957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as the flip isoform). RNA editing changes Gln607Arg (CAG->CGG) and Arg764Gly (AGA->GGA).
    Source sequence(s)
    AF164344, CO400088, JAXUCZ010000002, M38061
    UniProtKB/TrEMBL
    A6J5S9, G3V914
    Related
    ENSRNOP00000072906.2, ENSRNOT00000083361.3
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    168247490..168367616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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