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Bpi bactericidal/permeability-increasing protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 296321, updated on 4-Jan-2025

Summary

Official Symbol
Bpiprovided by RGD
Official Full Name
bactericidal/permeability-increasing proteinprovided by RGD
Primary source
RGD:1303179
See related
EnsemblRapid:ENSRNOG00000034195 AllianceGenome:RGD:1303179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bpifd1
Summary
Enables lipopolysaccharide binding activity. Involved in defense response to bacterium and immune response. Predicted to be located in cytoplasmic stress granule. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Crohn's disease. Orthologous to human BPI (bactericidal permeability increasing protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 54.3) See more
Orthologs
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Genomic context

See Bpi in Genome Data Viewer
Location:
3q42
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (167329513..167356217)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (146909626..146936487)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (154741627..154768584)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transglutaminase 2 Neighboring gene uncharacterized LOC134486469 Neighboring gene KIAA1755 ortholog Neighboring gene lipopolysaccharide binding protein Neighboring gene dynactin subunit 5, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Clone Names

  • MGC94477

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding  
enables lipid binding PubMed 
enables lipopolysaccharide binding  
enables lipopolysaccharide binding PubMed 
enables lipopolysaccharide binding  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium  
involved_in defense response to Gram-negative bacterium  
involved_in defense response to bacterium PubMed 
involved_in immune response PubMed 
involved_in innate immune response  
involved_in innate immune response  
involved_in lipopolysaccharide-mediated signaling pathway  
involved_in negative regulation of interleukin-6 production  
involved_in negative regulation of interleukin-6 production  
involved_in negative regulation of interleukin-8 production  
involved_in negative regulation of interleukin-8 production  
involved_in negative regulation of macrophage activation  
involved_in negative regulation of macrophage activation  
involved_in negative regulation of tumor necrosis factor production  
involved_in negative regulation of tumor necrosis factor production  
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoplasmic stress granule  
is_active_in extracellular space  
located_in extracellular space  
located_in membrane  

General protein information

Preferred Names
bactericidal permeability-increasing protein
Names
BPI fold containing family D, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004079.2NP_001004079.1  bactericidal permeability-increasing protein precursor

    See identical proteins and their annotated locations for NP_001004079.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q6AXU0
    UniProtKB/TrEMBL
    A0A8L2QQX2
    Related
    ENSRNOP00000098690.1, ENSRNOT00000140998.1
    Conserved Domains (2) summary
    smart00328
    Location:35259
    BPI1; BPI/LBP/CETP N-terminal domain
    cl00188
    Location:246480
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    167329513..167356217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104626.2XP_038960554.1  bactericidal permeability-increasing protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6A2Q9
    Related
    ENSRNOP00000107568.1, ENSRNOT00000170063.1
    Conserved Domains (2) summary
    smart00328
    Location:35259
    BPI1; BPI/LBP/CETP N-terminal domain
    cl00188
    Location:246443
    BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...
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