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Adam7 ADAM metallopeptidase domain 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29641, updated on 13-Apr-2024

Summary

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Official Symbol
Adam7provided by RGD
Official Full Name
ADAM metallopeptidase domain 7provided by RGD
Primary source
RGD:62032
See related
Ensembl:ENSRNOG00000014054 AllianceGenome:RGD:62032
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
EAP; ADAM; EAPI; EAP I; ADAM 7
Summary
Predicted to enable endopeptidase activity and metallopeptidase activity. Predicted to be involved in integrin-mediated signaling pathway and proteolysis. Located in apical part of cell. Orthologous to human ADAM7 (ADAM metallopeptidase domain 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 17.0) See more
Orthologs
human mouse all
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Genomic context

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See Adam7 in Genome Data Viewer
Location:
15p11
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (47009176..47057581, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (42833796..42882201, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (49418946..49467174, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097024 Neighboring gene uncharacterized LOC134481980 Neighboring gene ADAM-like, decysin 1 Neighboring gene disintegrin and metalloproteinase domain-containing protein 28-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A mammalian epididymal protein with remarkable sequence similarity to snake venom haemorrhagic peptides. Perry AC, et al. Biochem J, 1992 Sep 15. PMID 1417724, Free PMC Article
  2. Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Choi H, et al. Biol Reprod, 2015 Sep. PMID 26246218
  3. Molecular, biochemical, and cellular characterization of epididymal ADAMs, ADAM7 and ADAM28. Oh J, et al. Biochem Biophys Res Commun, 2005 Jun 17. PMID 15883027
  4. Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Yang LT, et al. Mol Biol Cell, 2005 Feb. PMID 15574878, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in epididymis development IEA
Inferred from Electronic Annotation
more info
  
involved_in epididymis development ISO
Inferred from Sequence Orthology
more info
  
involved_in epididymis development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epithelial cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of sperm capacitation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of sperm capacitation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sperm capacitation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 7
Names
a disintegrin and metallopeptidase domain 7
a disintegrin and metalloprotease domain (ADAM) 7
a disintegrin and metalloprotease domain 7
epididymal apical protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020301.2 → NP_064697.2  disintegrin and metalloproteinase domain-containing protein 7 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    Q63180
    UniProtKB/TrEMBL
    A6K6R3, G3V7T7
    Related
    ENSRNOP00000019209.2, ENSRNOT00000019209.3
    Conserved Domains (4) summary
    smart00050
    Location:410 → 482
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:486 → 623
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:199 → 393
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:28 → 156
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    47009176..47057581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63180.1 GenPept UniProtKB/Swiss-Prot:Q63180

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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