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Zswim2 zinc finger, SWIM-type containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296455, updated on 10-May-2024

Summary

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Official Symbol
Zswim2provided by RGD
Official Full Name
zinc finger, SWIM-type containing 2provided by RGD
Primary source
RGD:1311373
See related
Ensembl:ENSRNOG00000032579 AllianceGenome:RGD:1311373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein self-association and ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to act upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Orthologous to human ZSWIM2 (zinc finger SWIM-type containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 173.6) See more
Orthologs
human mouse all
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Genomic context

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Location:
3q24
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (89401887..89422308, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (68993422..69015441, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (71274341..71295641, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 171, member B Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene transfer RNA proline (anticodon AGG) 5 Neighboring gene uncharacterized LOC134486292

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Nishito Y, et al. Biochem J, 2006 Jun 15. PMID 16522193, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ZSWIM2
Names
zinc finger SWIM domain-containing protein 2
zinc finger, SWIM domain containing 2
NP_001011960.1
XP_038960590.1
XP_063139488.1
XP_063139489.1
XP_063139490.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011960.2 → NP_001011960.1  E3 ubiquitin-protein ligase ZSWIM2 isoform 1

    See identical proteins and their annotated locations for NP_001011960.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2JZ24, A0A8J8XBL1, E9PTV6, Q68FQ1
    Related
    ENSRNOP00000070884.1, ENSRNOT00000083015.2
    Conserved Domains (3) summary
    pfam04434
    Location:54 → 86
    SWIM; SWIM zinc finger
    pfam13639
    Location:343 → 386
    zf-RING_2; Ring finger domain
    cl00295
    Location:233 → 276
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...

  2. NM_001430311.1 → NP_001417240.1  E3 ubiquitin-protein ligase ZSWIM2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001430312.1 → NP_001417241.1  E3 ubiquitin-protein ligase ZSWIM2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RNA

  1. NR_190887.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    89401887..89422308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104662.2 → XP_038960590.1  E3 ubiquitin-protein ligase ZSWIM2 isoform X3

    Conserved Domains (3) summary
    pfam04434
    Location:54 → 86
    SWIM; SWIM zinc finger
    cd16494
    Location:144 → 202
    RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
    cl00295
    Location:233 → 276
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...

  2. XM_063283419.1 → XP_063139489.1  E3 ubiquitin-protein ligase ZSWIM2 isoform X2

  3. XM_063283418.1 → XP_063139488.1  E3 ubiquitin-protein ligase ZSWIM2 isoform X1

  4. XM_063283420.1 → XP_063139490.1  E3 ubiquitin-protein ligase ZSWIM2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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