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Cask calcium/calmodulin dependent serine protein kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 29647, updated on 2-May-2024

Summary

Symbol
Caskprovided by RGD
Full Name
calcium/calmodulin dependent serine protein kinaseprovided by RGD
Primary source
RGD:62004
See related
Ensembl:ENSRNOG00000060946 AllianceGenome:RGD:62004
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables PDZ domain binding activity; neurexin family protein binding activity; and protein C-terminus binding activity. Involved in several processes, including nervous system development; positive regulation of insulin secretion; and protein localization to plasma membrane. Located in several cellular components, including apical dendrite; basolateral plasma membrane; and podocyte foot. Part of protein-containing complex. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 149.8), Adrenal (RPKM 92.5) and 9 other tissues See more
Orthologs
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Genomic context

Location:
Xq12
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (11572328..11915831)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (8899500..9243014)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (9815652..10156155)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene SNW domain containing 1, pseudogene 6 Neighboring gene transfer RNA glutamine (anticodon UUG) 5 Neighboring gene uncharacterized LOC120099226 Neighboring gene G protein-coupled receptor 82 Neighboring gene G protein-coupled receptor 34 Neighboring gene transfer RNA aspartic acid (anticodon GUC) 13 Neighboring gene nyctalopin Neighboring gene uncharacterized LOC120099244

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables neurexin family protein binding IEA
Inferred from Electronic Annotation
more info
 
enables neurexin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables neurexin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in calcium ion import IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebral cortex development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in apical dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear lamina ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in podocyte foot IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peripheral plasma membrane protein CASK
Names
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
peripheral plasma membrane protein CASK-like
NP_071520.1
XP_038955486.1
XP_038955487.1
XP_038955488.1
XP_038955489.1
XP_038955490.1
XP_038955491.1
XP_038955492.1
XP_038955493.1
XP_038955494.1
XP_038955495.1
XP_063135934.1
XP_063135935.1
XP_063135937.1
XP_063135938.1
XP_063135939.1
XP_063135940.1
XP_063135941.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022184.1NP_071520.1  peripheral plasma membrane protein CASK

    See identical proteins and their annotated locations for NP_071520.1

    Status: PROVISIONAL

    Source sequence(s)
    U47110
    UniProtKB/Swiss-Prot
    Q62915
    UniProtKB/TrEMBL
    A0A0G2K2L8
    Related
    ENSRNOP00000072295.1, ENSRNOT00000091382.2
    Conserved Domains (8) summary
    smart00569
    Location:348401
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12081
    Location:604665
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    smart00072
    Location:731897
    GuKc; Guanylate kinase homologues
    smart00220
    Location:12276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:488568
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:721894
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:406456
    L27; L27 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    11572328..11915831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279864.1XP_063135934.1  peripheral plasma membrane protein CASK isoform X2

  2. XM_039099558.2XP_038955486.1  peripheral plasma membrane protein CASK isoform X1

    UniProtKB/TrEMBL
    A6JZX5
    Conserved Domains (6) summary
    smart00569
    Location:354407
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12081
    Location:622683
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    cd00992
    Location:494574
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8313
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:744917
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:412462
    L27; L27 domain
  3. XM_039099563.2XP_038955491.1  peripheral plasma membrane protein CASK isoform X7

    UniProtKB/TrEMBL
    A6JZX5
    Conserved Domains (6) summary
    smart00569
    Location:354407
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12081
    Location:610671
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    cd00992
    Location:494574
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8313
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:732905
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:412462
    L27; L27 domain
  4. XM_063279869.1XP_063135939.1  peripheral plasma membrane protein CASK isoform X14

  5. XM_063279867.1XP_063135937.1  peripheral plasma membrane protein CASK isoform X10

  6. XM_039099560.2XP_038955488.1  peripheral plasma membrane protein CASK isoform X4

    UniProtKB/TrEMBL
    A6JZX5
    Conserved Domains (6) summary
    smart00569
    Location:348401
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12081
    Location:616677
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    cd00992
    Location:488568
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8313
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:738911
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:406456
    L27; L27 domain
  7. XM_063279865.1XP_063135935.1  peripheral plasma membrane protein CASK isoform X8

  8. XM_039099561.2XP_038955489.1  peripheral plasma membrane protein CASK isoform X5

    UniProtKB/TrEMBL
    A0A0G2K2L8, A0A8I6GLU3
    Related
    ENSRNOP00000096945.1
    Conserved Domains (6) summary
    smart00569
    Location:348401
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12081
    Location:616677
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    cd00992
    Location:488568
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:733906
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:406456
    L27; L27 domain
  9. XM_039099564.2XP_038955492.1  peripheral plasma membrane protein CASK isoform X9

    UniProtKB/TrEMBL
    A0A8I6APQ1
    Conserved Domains (6) summary
    smart00569
    Location:354407
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12081
    Location:599660
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    cd00992
    Location:494574
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8313
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:721894
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:412462
    L27; L27 domain
  10. XM_039099559.2XP_038955487.1  peripheral plasma membrane protein CASK isoform X3

    UniProtKB/TrEMBL
    A6JZX4, A6JZX5
    Conserved Domains (6) summary
    smart00569
    Location:348401
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12081
    Location:616677
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    cd00992
    Location:488568
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:738911
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:406456
    L27; L27 domain
  11. XM_063279868.1XP_063135938.1  peripheral plasma membrane protein CASK isoform X11

  12. XM_039099565.2XP_038955493.1  peripheral plasma membrane protein CASK isoform X12

    UniProtKB/TrEMBL
    A0A8I6APQ1
    Conserved Domains (6) summary
    smart00569
    Location:348401
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12081
    Location:593654
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    cd00992
    Location:488568
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:710883
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:406456
    L27; L27 domain
  13. XM_039099562.2XP_038955490.1  peripheral plasma membrane protein CASK isoform X6

    UniProtKB/TrEMBL
    A6JZX5, D4A8M2
    Related
    ENSRNOP00000004187.7
    Conserved Domains (6) summary
    smart00569
    Location:342395
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12081
    Location:610671
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    cd00992
    Location:482562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:732905
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:400450
    L27; L27 domain
  14. XM_039099567.2XP_038955495.1  peripheral plasma membrane protein CASK isoform X17

    UniProtKB/TrEMBL
    A6JZX6
    Conserved Domains (6) summary
    smart00569
    Location:342395
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12081
    Location:575636
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    cd00992
    Location:482562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:692865
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:400450
    L27; L27 domain
  15. XM_063279870.1XP_063135940.1  peripheral plasma membrane protein CASK isoform X15

  16. XM_063279871.1XP_063135941.1  peripheral plasma membrane protein CASK isoform X16

    UniProtKB/TrEMBL
    A0A0G2K8F4
  17. XM_039099566.2XP_038955494.1  peripheral plasma membrane protein CASK isoform X13

    UniProtKB/TrEMBL
    A0A8I6APQ1
    Conserved Domains (6) summary
    smart00569
    Location:342395
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12081
    Location:587648
    SH3_CASK; Src Homology 3 domain of Calcium/calmodulin-dependent Serine protein Kinase
    cd00992
    Location:482562
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd14094
    Location:8307
    STKc_CASK; Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase
    pfam00625
    Location:709882
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:400450
    L27; L27 domain