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Npdc1 neural proliferation, differentiation and control, 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296562, updated on 5-Mar-2024

Summary

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Official Symbol
Npdc1provided by RGD
Official Full Name
neural proliferation, differentiation and control, 1provided by RGD
Primary source
RGD:1303156
See related
Ensembl:ENSRNOG00000013102 AllianceGenome:RGD:1303156
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be integral component of membrane. Orthologous to human NPDC1 (neural proliferation, differentiation and control 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 165.9), Lung (RPKM 152.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3p13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28618601..28624591)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8220446..8226446)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2624231..2630672)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene suppressor APC domain containing 2 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2 Neighboring gene ribosomal protein L28, pseudogene 4 Neighboring gene fucosyltransferase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subcellular localization of neural-specific NPDC-1 protein. Evrard C, et al. J Neurosci Res, 2005 Mar 15. PMID 15678517
  2. NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif. Spencer ML, et al. J Biol Chem, 2004 Aug 27. PMID 15229225
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NPDC-1 has a role in regulating neuronal proliferation and is degraded by the ubiquitin/proteasome system through a PEST degradation motif
    Title: NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif.
  2. subcellular fractionation of rat brain showed that crude synaptic membrane and crude synaptic vesicle fractions were enriched in NPDC-1.
    Title: Subcellular localization of neural-specific NPDC-1 protein.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC94179

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neural proliferation differentiation and control protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004231.1 → NP_001004231.1  neural proliferation differentiation and control protein 1 precursor

    See identical proteins and their annotated locations for NP_001004231.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079156
    UniProtKB/TrEMBL
    A0A8I6AS12, Q6AY81
    Related
    ENSRNOP00000096205.1, ENSRNOT00000112091.1
    Conserved Domains (1) summary
    pfam06809
    Location:1 → 331
    NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    28618601..28624591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104710.2 → XP_038960638.1  neural proliferation differentiation and control protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AS12
    Conserved Domains (1) summary
    pfam06809
    Location:1 → 347
    NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)

  2. XM_039104713.2 → XP_038960641.1  neural proliferation differentiation and control protein 1 isoform X5

    UniProtKB/TrEMBL
    A6JT57
    Conserved Domains (1) summary
    pfam06809
    Location:1 → 281
    NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)

  3. XM_039104711.2 → XP_038960639.1  neural proliferation differentiation and control protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AS12
    Conserved Domains (1) summary
    pfam06809
    Location:1 → 330
    NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)

  4. XM_017591629.3 → XP_017447118.1  neural proliferation differentiation and control protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AS12, F7EWX9
    Related
    ENSRNOP00000018927.4

  5. XM_006233584.5 → XP_006233646.1  neural proliferation differentiation and control protein 1 isoform X4

    UniProtKB/TrEMBL
    A6JT57
    Conserved Domains (1) summary
    pfam06809
    Location:1 → 282
    NPDC1; Neural proliferation differentiation control-1 protein (NPDC1)
Nucleotide Protein Strain
Heading Accession and Version

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