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Prrc2b proline-rich coiled-coil 2B [ Rattus norvegicus (Norway rat) ]

Gene ID: 296637, updated on 4-Apr-2024

Summary

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Official Symbol
Prrc2bprovided by RGD
Official Full Name
proline-rich coiled-coil 2Bprovided by RGD
Primary source
RGD:1595906
See related
Ensembl:ENSRNOG00000010217 AllianceGenome:RGD:1595906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bat2l
Summary
Predicted to be involved in cell differentiation. Predicted to act upstream of or within in utero embryonic development. Orthologous to human PRRC2B (proline rich coiled-coil 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 188.6), Kidney (RPKM 173.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prrc2b in Genome Data Viewer
Location:
3p12
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (35831017..35916854)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15433357..15519105)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11165687..11252401)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase 7 (inactive) Neighboring gene uncharacterized LOC120101521 Neighboring gene uncharacterized LOC103691765 Neighboring gene small nucleolar RNA, C/D box 62A Neighboring gene small nucleolar RNA, C/D box 62B Neighboring gene protein-O-mannosyltransferase 1 Neighboring gene uncharacterized LOC134486071 Neighboring gene uridine-cytidine kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of proline-rich coiled-coil 2B protein in developing rat brains. Mei Q, et al. Neurosci Lett, 2013 Dec 17. PMID 24466597
  2. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein PRRC2B
Names
protein BAT2-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134518.1 → NP_001127990.1  protein PRRC2B isoform 2

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    CH474001
    UniProtKB/TrEMBL
    A6JU43
    Conserved Domains (2) summary
    PHA03247
    Location:1227 → 1495
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  2. NM_001371270.3 → NP_001358199.1  protein PRRC2B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D3ZY45
    Related
    ENSRNOP00000013546.7, ENSRNOT00000013546.7
    Conserved Domains (2) summary
    PHA03247
    Location:1916 → 2184
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    35831017..35916854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234005.3 → XP_006234067.1  protein PRRC2B isoform X1

    See identical proteins and their annotated locations for XP_006234067.1

    UniProtKB/TrEMBL
    D3ZY45, D3ZZ51
    Related
    ENSRNOP00000063117.4
    Conserved Domains (2) summary
    PHA03247
    Location:1917 → 2185
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  2. XM_039104756.2 → XP_038960684.1  protein PRRC2B isoform X3

    UniProtKB/TrEMBL
    D3ZY45
    Conserved Domains (2) summary
    pfam09606
    Location:1884 → 2131
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  3. XM_039104755.2 → XP_038960683.1  protein PRRC2B isoform X2

    UniProtKB/TrEMBL
    D3ZY45
    Conserved Domains (2) summary
    PHA03247
    Location:1916 → 2184
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  4. XM_063283492.1 → XP_063139562.1  protein PRRC2B isoform X4

  5. XM_039104757.2 → XP_038960685.1  protein PRRC2B isoform X5

    UniProtKB/TrEMBL
    A0A0G2KAU9
    Related
    ENSRNOP00000075535.2
    Conserved Domains (2) summary
    PHA03247
    Location:1228 → 1496
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  6. XM_039104759.2 → XP_038960687.1  protein PRRC2B isoform X8

    Conserved Domains (2) summary
    PHA03247
    Location:1228 → 1442
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  7. XM_039104758.2 → XP_038960686.1  protein PRRC2B isoform X6

    UniProtKB/TrEMBL
    A6JU43
    Conserved Domains (2) summary
    PHA03247
    Location:1227 → 1495
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus

  8. XM_063283493.1 → XP_063139563.1  protein PRRC2B isoform X7

  9. XM_039104754.2 → XP_038960682.1  protein PRRC2B isoform X1

    UniProtKB/TrEMBL
    D3ZY45, D3ZZ51
    Conserved Domains (2) summary
    PHA03247
    Location:1917 → 2185
    PHA03247; large tegument protein UL36; Provisional
    pfam07001
    Location:1 → 189
    BAT2_N; BAT2 N-terminus
Nucleotide Protein Strain
Heading Accession and Version

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