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Zc3h12b zinc finger CCCH-type containing 12B [ Rattus norvegicus (Norway rat) ]

Gene ID: 296864, updated on 5-Mar-2024

Summary

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Official Symbol
Zc3h12bprovided by RGD
Official Full Name
zinc finger CCCH-type containing 12Bprovided by RGD
Primary source
RGD:1560891
See related
Ensembl:ENSRNOG00000011508 AllianceGenome:RGD:1560891
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560891
Summary
Predicted to enable endoribonuclease activity and mRNA binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12B (zinc finger CCCH-type containing 12B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 27.3), Uterus (RPKM 5.2) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zc3h12b in Genome Data Viewer
Location:
Xq22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (64625479..64858634)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (60615616..60849278)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (65040032..65074857)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene adenylosuccinate lyase, pseudogene 1 Neighboring gene BAF nuclear assembly factor 1, pseudogene 2 Neighboring gene alpha- and gamma-adaptin binding protein, pseudogene 1 Neighboring gene DLG associated protein 4, pseudogene 1 Neighboring gene uncharacterized LOC102550969 Neighboring gene LAS1-like, ribosome biogenesis factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable ribonuclease ZC3H12B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    64625479..64858634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100436.2 → XP_038956364.1  probable ribonuclease ZC3H12B isoform X1

    UniProtKB/TrEMBL
    A6IQ32, D4ACQ4
    Related
    ENSRNOP00000045289.3
    Conserved Domains (4) summary
    cd18729
    Location:192 → 322
    PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
    pfam18039
    Location:107 → 148
    UBA_6; UBA-like domain
    pfam18044
    Location:359 → 377
    zf-CCCH_4; CCCH-type zinc finger
    pfam18561
    Location:795 → 829
    Regnase_1_C; Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain

  2. XM_063280452.1 → XP_063136522.1  probable ribonuclease ZC3H12B isoform X2

  3. XM_002730248.7 → XP_002730294.1  probable ribonuclease ZC3H12B isoform X1

    See identical proteins and their annotated locations for XP_002730294.1

    UniProtKB/TrEMBL
    A6IQ32, D4ACQ4
    Conserved Domains (4) summary
    cd18729
    Location:192 → 322
    PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins
    pfam18039
    Location:107 → 148
    UBA_6; UBA-like domain
    pfam18044
    Location:359 → 377
    zf-CCCH_4; CCCH-type zinc finger
    pfam18561
    Location:795 → 829
    Regnase_1_C; Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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