Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp2a2provided by RGD
Official Full Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2provided by RGD
Primary source: RGD:2174
See related: Ensembl:ENSRNOG00000001285 AllianceGenome:RGD:2174
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Serca2; SercaII
Summary: Enables several functions, including ATP binding activity; P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential; and lutropin-choriogonadotropic hormone receptor binding activity. Involved in several processes, including calcium ion transport; regulation of cardiac muscle cell membrane potential; and regulation of cardiac muscle contraction. Located in several cellular components, including apical ectoplasmic specialization; perinuclear region of cytoplasm; and sarcoplasmic reticulum. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Used to study abdominal obesity-metabolic syndrome 1; congestive heart failure; and type 2 diabetes mellitus. Biomarker of euthyroid sick syndrome; heart disease; hypothyroidism; pulmonary hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 15861.0), Muscle (RPKM 2107.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (39733519..39782942)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (34072710..34122142)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (39553903..39603326)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Remote ischemic postconditioning alleviates cerebral ischemic injury through SERCA2/endoplasmic reticulum stress-mediated apoptosis.
Title: Remote ischemic postconditioning alleviates cerebral ischemic injury through SERCA2/endoplasmic reticulum stress-mediated apoptosis.
Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca[2+] waves.
Title: Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca(2+) waves.
Effects of MiR-214-3p Regulation of SERCA2a Expression on Contractility of Cardiomyocytes in Heart Failure Model.
Title: Effects of MiR-214-3p Regulation of SERCA2a Expression on Contractility of Cardiomyocytes in Heart Failure Model.
Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia/reperfusion injury in rats by upregulating SERCA2a.
Title: Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia/reperfusion injury in rats by upregulating SERCA2a.
Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool.
Title: Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool.
Relative role of T-tubules disruption and decreased SERCA2 on contractile dynamics of isolated rat ventricular myocytes.
Title: Relative role of T-tubules disruption and decreased SERCA2 on contractile dynamics of isolated rat ventricular myocytes.
Roles of sarcoplasmic reticulum Ca(2+) ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model.
Title: Roles of sarcoplasmic reticulum Ca(2+) ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model.
Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring.
Title: Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring.
Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischaemia-reperfusion injury.
Title: Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischaemia-reperfusion injury.
MicroRNA-30b regulates insulin sensitivity by targeting SERCA2b in non-alcoholic fatty liver disease.
Title: MicroRNA-30b regulates insulin sensitivity by targeting SERCA2b in non-alcoholic fatty liver disease.

Submit: New GeneRIF Correction See all GeneRIFs (92)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G15902 (e-PCR)
- UniSTS:4216

D12S2026 (e-PCR)
- UniSTS:21224

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	ISO Inferred from Sequence Orthology more info
enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	ISO Inferred from Sequence Orthology more info
enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	ISS Inferred from Sequence or Structural Similarity more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	IEA Inferred from Electronic Annotation more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables lutropin-choriogonadotropic hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ER-nucleus signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ER-nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T-tubule organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T-tubule organization	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagosome membrane docking	ISO Inferred from Sequence Orthology more info
involved_in autophagosome membrane docking	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion import into sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion import into sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import into sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport from cytosol to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy in response to stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in organelle localization by membrane tethering	ISO Inferred from Sequence Orthology more info
involved_in organelle localization by membrane tethering	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endoplasmic reticulum calcium ion concentration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of endoplasmic reticulum calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endoplasmic reticulum calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion-dependent exocytosis of neurotransmitter	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of calcium ion-dependent exocytosis of neurotransmitter	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cardiac muscle cell membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cardiac muscle cell membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by calcium ion signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cardiac muscle contraction by calcium ion signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cardiac muscle contraction by calcium ion signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in relaxation of cardiac muscle	IDA Inferred from Direct Assay more info	PubMed
involved_in relaxation of cardiac muscle	ISO Inferred from Sequence Orthology more info
involved_in relaxation of skeletal muscle	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to endoplasmic reticulum stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in sarcoplasmic reticulum calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sarcoplasmic reticulum calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in transition between fast and slow fiber	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transition between fast and slow fiber	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical ectoplasmic specialization	IDA Inferred from Direct Assay more info	PubMed
part_of calcium ion-transporting ATPase complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in longitudinal sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane bounded cell projection	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in ribbon synapse	IEA Inferred from Electronic Annotation more info
located_in ribbon synapse	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in sarcoplasmic reticulum membrane	IC Inferred by Curator more info	PubMed
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Names: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; SR Ca(2+)-ATPase 2; calcium pump 2; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2

NP_001103609.1

EC 7.2.2.10

NP_001104293.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110139.2 → NP_001103609.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a

See identical proteins and their annotated locations for NP_001103609.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 3. The resulting isoform (a), also known as SERCA2A, has a shorter and distinct C-terminus compared to isoform b.

Source sequence(s)

CK356436, CK356454, EV765256, J04022, J04023, J04024, JAXUCZ010000012

UniProtKB/TrEMBL

A0A8L2QDW2

Conserved Domains (6) summary

TIGR01116
Location:53 → 988

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:93 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:783 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:605 → 711

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 527

Cation_ATPase; Cation transport ATPase (P-type)
NM_001110823.2 → NP_001104293.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b

See identical proteins and their annotated locations for NP_001104293.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longer isoform (b), also known as SERCA2B.

Source sequence(s)

AA900747, BE119640, CK356454, CK358684, J04022, J04024

UniProtKB/Swiss-Prot

P11507, P11508

UniProtKB/TrEMBL

A0A8L2QDW2

Related

ENSRNOP00000001738.7, ENSRNOT00000001738.8

Conserved Domains (6) summary

TIGR01116
Location:53 → 988

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:93 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:783 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:605 → 711

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 527

Cation_ATPase; Cation transport ATPase (P-type)

RNA

NR_027839.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents a longer 3' UTR, compared to variant 3. This variant is represented as non-coding because the additional splicing in the 3' UTR renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BE119640, CK356436, CK356454, CK358684, CO404645, J04022, J04024