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Elmod3 ELMO domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297342, updated on 11-Apr-2024

Summary

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Official Symbol
Elmod3provided by RGD
Official Full Name
ELMO domain containing 3provided by RGD
Primary source
RGD:1306408
See related
Ensembl:ENSRNOG00000038102 AllianceGenome:RGD:1306408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kcmf1; Rbed1
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of catalytic activity. Predicted to be located in several cellular components, including cytoskeleton; kinocilium; and stereocilium. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 88. Orthologous to human ELMOD3 (ELMO domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 181.1), Adrenal (RPKM 52.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Elmod3 in Genome Data Viewer
Location:
4q32
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (106172819..106211286, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104614665..104653122, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (100422256..100465152, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 6 Neighboring gene transfer RNA proline (anticodon AGG) 74 Neighboring gene capping actin protein, gelsolin like Neighboring gene retinol saturase Neighboring gene trans-golgi network protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs. Bowzard JB, et al. J Biol Chem, 2007 Jun 15. PMID 17452337
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within auditory receptor cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within stereocilium maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinocilium IEA
Inferred from Electronic Annotation
more info
  
located_in stereocilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ELMO domain-containing protein 3
Names
ELMO/CED-12 domain containing 3
RNA binding motif and ELMO domain 1
RNA-binding motif and ELMO domain-containing protein 1
potassium channel modulatory factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013087.1 → NP_001013105.1  ELMO domain-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001013105.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083623
    UniProtKB/Swiss-Prot
    Q5XIQ2
    UniProtKB/TrEMBL
    A0A8I6AFQ0
    Related
    ENSRNOP00000054799.3, ENSRNOT00000057989.4
    Conserved Domains (1) summary
    pfam04727
    Location:159 → 308
    ELMO_CED12; ELMO/CED-12 family

  2. NM_001398834.1 → NP_001385763.1  ELMO domain-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2KBB8
    Related
    ENSRNOP00000075730.1, ENSRNOT00000086725.2
    Conserved Domains (1) summary
    pfam04727
    Location:155 → 313
    ELMO_CED12; ELMO/CED-12 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    106172819..106211286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762978.4 → XP_008761200.1  ELMO domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_008761200.1

    UniProtKB/TrEMBL
    A0A0G2KBB8, A0A8I6AFQ0
    Conserved Domains (1) summary
    pfam04727
    Location:155 → 313
    ELMO_CED12; ELMO/CED-12 family

  2. XM_063285782.1 → XP_063141852.1  ELMO domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KBB8

  3. XM_017592542.3 → XP_017448031.1  ELMO domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KBB8, A0A8I6AFQ0
    Conserved Domains (1) summary
    pfam04727
    Location:155 → 313
    ELMO_CED12; ELMO/CED-12 family

  4. XM_063285781.1 → XP_063141851.1  ELMO domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KBB8

  5. XM_063285785.1 → XP_063141855.1  ELMO domain-containing protein 3 isoform X3

  6. XM_063285783.1 → XP_063141853.1  ELMO domain-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q5XIQ2

  7. XM_063285784.1 → XP_063141854.1  ELMO domain-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q5XIQ2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIQ2.1 GenPept UniProtKB/Swiss-Prot:Q5XIQ2

Gene LinkOut

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