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Ctnna2 catenin alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297357, updated on 13-Apr-2024

Summary

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Official Symbol
Ctnna2provided by RGD
Official Full Name
catenin alpha 2provided by RGD
Primary source
RGD:1305060
See related
Ensembl:ENSRNOG00000006003 AllianceGenome:RGD:1305060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Catna2
Summary
Predicted to enable actin filament binding activity; beta-catenin binding activity; and identical protein binding activity. Predicted to be involved in several processes, including modification of postsynaptic actin cytoskeleton; negative regulation of Arp2/3 complex-mediated actin nucleation; and nervous system development. Predicted to be located in several cellular components, including basolateral plasma membrane; lamellipodium; and postsynaptic density. Predicted to be part of catenin complex. Predicted to be active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density, intracellular component. Predicted to be extrinsic component of postsynaptic membrane and extrinsic component of presynaptic membrane. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human CTNNA2 (catenin alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 205.3) and Testes (RPKM 103.8) See more
Orthologs
human mouse all
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Genomic context

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Location:
4q33
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (110852265..112001351, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (109294249..110443409, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (107880611..109042724, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L6, pseudogene 15 Neighboring gene U6 spliceosomal RNA Neighboring gene leucine rich repeat transmembrane neuronal 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene U11 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biallelic loss of human CTNNA2, encoding αN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration. Schaffer AE, et al. Nat Genet, 2018 Aug. PMID 30013181, Free PMC Article
  2. Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin. Abe K, et al. Nat Neurosci, 2004 Apr. PMID 15034585
  3. Cadherin regulates dendritic spine morphogenesis. Togashi H, et al. Neuron, 2002 Jul 3. PMID 12123610
  4. Differential expression of alpha-E-catenin and alpha-N-catenin in the developing cerebral cortex. Stocker AM, et al. Brain Res, 2006 Feb 16. PMID 16457793
  5. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. Bogaerts S, et al. Exp Cell Res, 2005 Nov 15. PMID 16182284

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in brain morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in prepulse inhibition ISO
Inferred from Sequence Orthology
more info
  
involved_in radial glia guided migration of Purkinje cell ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synapse structural plasticity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone cytoplasmic component ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
catenin alpha-2
Names
catenin (cadherin associated protein), alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106598.2 → NP_001100068.1  catenin alpha-2 isoform 1

    See identical proteins and their annotated locations for NP_001100068.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JYF7, A6IAF1
    Conserved Domains (1) summary
    pfam01044
    Location:81 → 914
    Vinculin; Vinculin family

  2. NM_001415842.1 → NP_001402771.1  catenin alpha-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    Related
    ENSRNOP00000007972.8, ENSRNOT00000007971.8

  3. NM_001415843.1 → NP_001402772.1  catenin alpha-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IAF1
    Related
    ENSRNOP00000070637.2, ENSRNOT00000080999.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    110852265..112001351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285787.1 → XP_063141857.1  catenin alpha-2 isoform X2

  2. XM_017592545.3 → XP_017448034.1  catenin alpha-2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYF7, A6IAF1
    Conserved Domains (1) summary
    pfam01044
    Location:81 → 914
    Vinculin; Vinculin family
Nucleotide Protein Strain
Heading Accession and Version

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