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Ccdc174 coiled-coil domain containing 174 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297458, updated on 5-Mar-2024

Summary

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Official Symbol
Ccdc174provided by RGD
Official Full Name
coiled-coil domain containing 174provided by RGD
Primary source
RGD:1305225
See related
Ensembl:ENSRNOG00000010090 AllianceGenome:RGD:1305225
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305225
Summary
Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human CCDC174 (coiled-coil domain containing 174). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 123.5), Lung (RPKM 93.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccdc174 in Genome Data Viewer
Location:
4q34
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (125949203..125976179)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (124392183..124419035)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (123760708..123787529)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548902 Neighboring gene solute carrier family 6 member 6 Neighboring gene glutamate receptor interacting protein 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene ribosomal protein S11, pseudogene 14 Neighboring gene uncharacterized LOC102554857 Neighboring gene similar to human chromosome 3 open reading frame 20 Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene uncharacterized LOC134486612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CDC174, a novel component of the exon junction complex whose mutation underlies a syndrome of hypotonia and psychomotor developmental delay. Volodarsky M, et al. Hum Mol Genet, 2015 Nov 15. PMID 26358778
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93974

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 174
Names
uncharacterized protein C3orf19 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009659.2 → NP_001009659.2  coiled-coil domain-containing protein 174

    See identical proteins and their annotated locations for NP_001009659.2

    Status: VALIDATED

    Source sequence(s)
    BC087050, BE106912, CA334689
    UniProtKB/Swiss-Prot
    Q5PQS7
    UniProtKB/TrEMBL
    A6IBB3, G3V7A6
    Related
    ENSRNOP00000013498.4, ENSRNOT00000013498.6
    Conserved Domains (1) summary
    pfam13300
    Location:238 → 311
    DUF4078; Domain of unknown function (DUF4078)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    125949203..125976179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236907.5 → XP_006236969.1  coiled-coil domain-containing protein 174 isoform X1

    UniProtKB/Swiss-Prot
    Q5PQS7
    Conserved Domains (1) summary
    pfam13300
    Location:238 → 311
    DUF4078; Domain of unknown function (DUF4078)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQS7.2 GenPept UniProtKB/Swiss-Prot:Q5PQS7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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