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Npbwr1 neuropeptides B and W receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297795, updated on 13-Apr-2024

Summary

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Official Symbol
Npbwr1provided by RGD
Official Full Name
neuropeptides B and W receptor 1provided by RGD
Primary source
RGD:1305917
See related
Ensembl:ENSRNOG00000007640 AllianceGenome:RGD:1305917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr7; Nbpwr1
Summary
Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within regulation of metabolic process. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human NPBWR1 (neuropeptides B and W receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See Npbwr1 in Genome Data Viewer
Location:
5q12
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (18282180..18285622)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (13495319..13498761)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (13379772..13380761)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549737 Neighboring gene uncharacterized LOC120102812 Neighboring gene proteasome 26S subunit, non-ATPase 12, pseudogene 1 Neighboring gene opioid receptor, kappa 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of NPB, NPW and Their Receptor in the Rat Heart. Pandey S, et al. Int J Mol Sci, 2020 Oct 22. PMID 33105700, Free PMC Article
  2. A study of the rat neuropeptide B/neuropeptide W system using in situ techniques. Jackson VR, et al. J Comp Neurol, 2006 Jul 20. PMID 16736466
  3. Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Ishii M, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12925742, Free PMC Article
  4. Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. Brezillon S, et al. J Biol Chem, 2003 Jan 10. PMID 12401809
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
neuropeptides B/W receptor type 1
Names
G-protein coupled receptor 7
neuropeptides B/W receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014784.2 → NP_001014784.1  neuropeptides B/W receptor type 1

    See identical proteins and their annotated locations for NP_001014784.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q56UD9
    Related
    ENSRNOP00000010032.2, ENSRNOT00000010032.3
    Conserved Domains (1) summary
    cd15087
    Location:40 → 320
    7tmA_NPBWR; neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    18282180..18285622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56UD9.1 GenPept UniProtKB/Swiss-Prot:Q56UD9

Gene LinkOut

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